Sökning: "lean mice"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden lean mice.

  1. 1. Oscillatory Ca2+ signaling in glucose-stimulated murine pancreatic β-cells : Modulation by amino acids, glucagon, caffeine and ryanodine

    Författare :Meftun Ahmed; Per Lindström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; pancreatic β-cells; islets of Langerhans; glucose; Ca2 oscillations; Ca2 transients; potassium; ryanodine; caffeine; glucagon; cAMP; inositol 1; 4; 5-trisphosphate; fura-2; glycine; alanine; arginine; Ca2 channels; rats; lean mice; ob ob mice; leptin; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Oscillations in cytoplasmic Ca2+ concentration ([Ca2+]i) is the key signal in glucose-stimulated β-cells governing pulsatile insulin release. The glucose response of mouse β-cells is often manifested as slow oscillations and rapid transients of [Ca2+] i. LÄS MER

  3. 2. The role of GH in the regulation of energy homeostasis, lipid metabolism and cardiovascular function in transgenic mice

    Författare :Bob Olsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; growth hormone; cardiovascular disease; energy homeostasis; lipid metabolism; transgenic mice;

    Sammanfattning : The aim of this thesis was, using two transgenic models, to investigate some metabolic diseases associated with acromegaly e.g. hypertension and alterations in lipid and lipoprotein metabolism. LÄS MER

  4. 3. Hypothalamic neuronal circuits involved in the regulation of food intake and body weight : histochemical studies in lean rats and obese mutant mice

    Författare :Matilda Bäckberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AGRP; arcuate nucleus; BBB; CART; GABA; GABA receptors; immunohistochemistry; in situ hybridization; hypothalamus; LHA; leptin; MCH; NPY; orexin; POMC; tubby;

    Sammanfattning : Obesity is a major health problem because of its dramatic increase in prevalence and its association with type 2 diabetes, coronary heart diseases, hypertension and stroke. It is well known that signals generated in response to feeding behavior are integrated in the brain. LÄS MER

  5. 4. On obesity in acute pancreatitis

    Författare :Ralf Segersvärd; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acute pancreatitis; animal; cytokines; dietary fats; fatty liver; endotoxin; hypertriglyceridemia; interleukines; lipopolysaccharides; liver diseases; mice; mortality; obesity; oxidative stress; pancreas; survival; tumor necrosis factor; rats; UCP2; uncoupling proteins.;

    Sammanfattning : Over-nutrition is one of today s most visible public health problems. Currently over 40% of the Swedish population is either overweight or obese. Acute pancreatitis (AP) is an acute inflammatory process of the pancreas with variable involvement of regional tissues and/or remote organ systems. LÄS MER

  7. 5. Interactions between nutrition, obesity and the immune system

    Författare :Louise Strandberg; Göteborgs universitet; []
    Nyckelord :obesity; nutrition; infection; polymorphisms; interleukin; fatty acids; fat mass; neutrophils; innate immunity; mortality;

    Sammanfattning : There are several links between body fat and the immune system. For example, mice lacking activity of the pro-inflammatory interleukin-(IL)-1 and IL-6 develop obesity. Conversely, obesity is associated with adipose tissue inflammation and increased risk of infection. LÄS MER