Sökning: "lathosterol"

Hittade 5 avhandlingar innehållade ordet lathosterol.

  1. 1. Smith-Lemli-Opitz syndrome - a disorder of cholesterol synthesis : Diagnosis, treatment and pathogenetic aspects

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Sciences and Technology

    Författare :Lena Starck; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Smith-Lemli-Opitz syndrome; cholesterol; cholesterol treatment; dehydrocholesterols; lathosterol; oxysterols; blood paper specimens; simvastatin; clinical scoring.;

    Sammanfattning : In 1993 it was first suggested that the Smith-Lemli-Opitz syndrome (SLOS), described almost 30 years earlier as a malformation syndrome, is caused by defective synthesis of cholesterol. Hypocholesterolaemia and accumulation of the immediate precursor 7dehydrocholesterol was consistent with deficient activity of the enzyme in the last step of the synthesis, 7-dehydrocholesterol-7-reductase. LÄS MER

  2. 2. Gallstone disease in a Swedish population : An epidemiological investigation

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Olle Muhrbeck; Karolinska Institutet.; Karolinska Institutet.; [1995]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cholelithiasis; cholecystectomy; cholesterol; epidemiologySweden; incidence; lathosterol; mass screening; prevalence; risk factors; symptoms; ultrasonography; 7-a-hydroxy-4-cholesten-3-one;

    Sammanfattning : Gallstones in a Swedish population. Olle MuhrbeckKarolinska Institutet, Division of Surgery, Danderyd Hospital, Stockholm, SwedenThe main objective of the present thesis was to study the prevalence ofgallstone disease in a community survey in Danderyd. LÄS MER

  3. 3. On the regulation of hepatic cholesterol and bile acid metabolism in gallstone patients

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Carl-Gustaf Hillebrant; Karolinska Institutet.; Karolinska Institutet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bile acid synthesis; biliary lipids; cholesterol synthesis; cholesterol 7a-hydroxylase; cholesterol synthesis inhibitor; chenodeoxycholic acid; cholestyramine; 7a-hydroxy-4-cholesten-3-one; HMG CoA reductase; lathosterol; lipoproteins; lithocholic acid; plasma apheresis; ursodeoxycholic acid;

    Sammanfattning : The liver plays an important role in the regulation of cholesterol homeostasis, therefore also in the pathogenesis of arteriosclerosis and gallstone disease. The quantitatively most important way by which cholesterol is removed from the human body is via the bile, either as free cholesterol or after transformation to bile acids. LÄS MER

  4. 4. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Kina Höglund; Göteborgs universitet.; Gothenburg University.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

    Sammanfattning : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. LÄS MER

  5. 5. 24s-Hydroxycholesterol. Studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Laboratory Medicine

    Författare :Marjan Shafaati; Karolinska Institutet.; Karolinska Institutet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC). This structural modification allows 24S-OHC to traverse the blood brain barrier and this pathway is the major one for elimination of cholesterol from the mammalian brain. LÄS MER