Sökning: "langerhanska öarna"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden langerhanska öarna.

  1. 1. Characterizing the pancreatic "isletome" : 3D optical imaging to study diabetes

    Författare :Max Hahn; Ulf Ahlgren; András Gorzsás; Leif Carlsson; Alvin C. Powers; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3D imaging; fluorescence microscopy; 3D image analysis; technique development; diabetes; Islet of Langerhans; Insulin; β-cell mass; pancreas; anatomy; molecular medicine medical sciences ; molekylär medicin medicinska vetenskaper ; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : The pancreas is a specialised multipurpose organ, that can be separated into two major compartments: endocrine and exocrine. The exocrine part makes up the majority of the organ volume and functions to secrete digestive enzymes into the small intestine. LÄS MER

  3. 2. GABA in the islets of Langerhans

    Författare :Anna Wendt; Diabetes - öcellsexocytos; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; secreting systems; diabetologi; sekretion; Endokrinologi; Endocrinology; SLMV; paracrine regulation; LDCV; islets of Langerhans; autocrine regulation; GABA; diabetology;

    Sammanfattning : GABA (γ-aminobutyric acid) is a well-known inhibitory neurotransmitter in the CNS. GABA is also present at high concentrations in the insulin-producing β-cells in the islets of Langerhans, but its function there is less clear. GABA is believed to accumulate in SLMVs (synaptic-like microvesicles). LÄS MER

  4. 3. The neuropeptides GRP and PACAP and the function of the endocrine pancreas - A study on receptor deficient mice

    Författare :Kristin Persson; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; hypoglycemia; glucagon; insulin; islet of Langerhans; diabetes; PACAP; neuropeptides; GRP; diabetologi;

    Sammanfattning : The parasympathetic nerves are important for the regulation of insulin secretion, in particular after meal intake. Apart from acetylcholine, several neuropeptides can be found in the parasympathetic nerves innervating the islets of Langerhans, including gastrin-releasing peptide (GRP) and pituitary adenylate cyclase activating polypeptide (PACAP). LÄS MER

  5. 4. Ghrelin and CART. Two new islet peptides. Expression, regulation and function

    Författare :Nils Wierup; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endokrinologi; sekretion; diabetologi; Endocrinology; secreting systems; diabetology; histology; endocrinology; islets; CART; Ghrelin cells; insulin secretion; type-2 diabetes; Ghrelin;

    Sammanfattning : Until recently, the islets of Langerhans were thought to harbour four main cell types characterised with respect to principal hormone product. Here we show that the novel hormone ghrelin is expressed in a fifth islet cell type, the islet ghrelin cell, in humans and rodents. LÄS MER

  7. 5. Nitric oxide (NO) and carbon monoxide (CO): A novel class of messenger molecules regulating insulin and glucagon secretion

    Författare :Ragnar Henningsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; carbon monoxide CO ; nitric oxide NO ; Nitric oxide synthase NOS ; Insulin and glucagon secretion; cyclic nucleotides; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi; Heme oxygenase HO ;

    Sammanfattning : During the last decade it has been shown that nitric oxide (NO) and carbon monoxide (CO) are produced in our own body, and that they constitute a novel class of messenger molecules. In 1992 a constitutive NO-producing NO-synthase (cNOS) was found in the islets of Langerhans, and in 1997 we could show for the first time that the islets also contained a CO-producing constitutive heme oxygenase (HO-2). LÄS MER