Sökning: "laminin α1"
Hittade 5 avhandlingar innehållade orden laminin α1.
1. Laminin-1 and receptors : Laminin α1 chain in important for epithelial development
Sammanfattning : Laminins are heterotrimeric glycoproteins that are major components of all basement membranes. Integrins from the β1 -famjly and the dystroglycan complex have been shown to be important receptors attaching epithelial cells to the underlying basement membrane. LÄS MER
2. The Laminins and their Receptors
Sammanfattning : Basement membranes are thin extracellular sheets that surround muscle, fat and peripheral nerve cells and underlay epithelial and endothelial cells. Laminins are one of the main protein families of these matrices. Integrins and dystroglycan are receptors for laminins, connecting cells to basement membranes. LÄS MER
3. Cellular Interactions with Extracellular Matrix During Development and in Muscle Disease
Sammanfattning : The formation and maintenance of tissues in multicellular animals are crucially dependent on cellular interactions with the extracellular matrix (ECM). Two different studies on such interactions are presented herein. LÄS MER
4. Gene expression studies of pregastrulation development: the basement membrane is essential for cell differentiation
Sammanfattning : Basement membranes (BMs) are sheet-like structures of extracellular matrix. They act as a supporting structure but can also significantly influence cellular behavior in development, tissue homeostasis and disease. Laminins, a major BM component, are multidomain proteins, consisting of three polypeptide chains (α, β and γ). LÄS MER
5. Studies of laminin a2 chain deficient mice -muscle sparing, charaterization of Cib2 and defective spermatorgenesis
Sammanfattning : Mutations in the gene encoding laminin α2 chain, an extracellular matrix protein mainly expressed in the neuromuscular system, cause a severe form of muscular dystrophy, congenital muscular dystrophy type 1A (MDC1A). Laminin α2 chain is associated to the muscle fibers by two major receptors, where one of them, integrin α7β1, is diminished upon laminin α2 chain deficiency. LÄS MER
