Sökning: "lactosamine"
Hittade 4 avhandlingar innehållade ordet lactosamine.
1. Synthesis of biologically active oligosaccharides of the Lewis b family and investigations towards the synthesis of glycoclusters
Sammanfattning : The gastric pathogen Helicobacter pylori is a Gram negative bacterium which may cause diseases such as peptic ulceration and gastric adenocarcinoma. It colonises a host by attaching to the gastric epithelial cells, an attachment mediated by outer membrane proteins on the bacterial surface, e.g, the blood group antigen binding adhesin, BabA. LÄS MER
2. Synthesis of lactosamine-containing carbohydrate structures and development for their easy assembly and conjugation
Sammanfattning : This thesis is based on four publications. The first chapter describes preparation of anomerically pure thioethyl-, thiophenyl-, and n-pentenyl 2-azido-2-deoxy glycosyl building blocks from easily accessible per-acetylated glycosamines. LÄS MER
3. Synthesis and chemical modification of some carbohydrates containing amino groups
Sammanfattning : The alkylation with alkyl trifluoromethanesulfonates of hydroxyl groups in carbohydrates, containing base- or acid-labile substituents, has been examined. The reagent simultaneously transforms acetamindo groups to N-methylamino groups. Synthesis and nitrous acid deamination of methyl 4-amino-4-deoxy-β-L-arabinopyranoside has been performed. LÄS MER
4. Multifaceted adhesion properties of Helicobacter pylori in promotion of gastric disease
Sammanfattning : Helicobacter pylori is a Gram-negative spiral-shaped bacteria that resides in the gastric mucosa and adheres to the epithelial lining of the human stomach. H. pylori adhesion mediates inflammation of the epithelium, which can lead to more severe diseases such as chronic active gastritis and gastric carcinoma. LÄS MER