Sökning: "lactam analogs"
Hittade 3 avhandlingar innehållade orden lactam analogs.
1. Synthetic analogs of sialyl Lewis x
Sammanfattning : The sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of leukocytes to a site of tissue damage or microbial infection. LÄS MER
2. Synthesis of Conformationally Restricted Oligosaccharides
Sammanfattning : Gangliosides are sialic acid-containing glycosphingolipids that often are present in increased amounts on tumor cells. Since the gangliosides are hydroxy-acids, they can form lactones. The lactones have been suspected to be more immunogenic than the open forms, but are in practise poor immunogens due to their ease of hydrolysis. LÄS MER
3. Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions : Ligands Targeting the Angiotensin II Type 2 Receptor
Sammanfattning : Palladium(0)-catalyzed chemistry represents one of the most important methods for the construction of carbon-carbon bonds, which are ubiquitous in organic compounds. The first part of this thesis describes the palladium(0)-catalyzed diastereoselective Mizoroki-Heck reaction of Vince lactam-derived precursors for the formation of spiroindolines (paper I) and spirooxindoles, which are scaffolds present in several natural products with interesting biological activity. LÄS MER