Sökning: "labelling chemistry"
Visar resultat 1 - 5 av 53 avhandlingar innehållade orden labelling chemistry.
1. Carborane Derivatives for Nuclide Therapy and Imaging : Synthesis and Radio-labelling
Sammanfattning : This thesis describes synthesis and radiohalogenation of closo-carborane and nido-carborate derivatives for application in nuclide therapy and imaging. The work could be divided in to four sections. LÄS MER
2. Development of new Fluorination Methods Directed to Fluorine-18 Labelling
Sammanfattning : This thesis deals with the development of new fluorination reactions and their application to fluorine-18 labelling. Fluorine-18 labelled compounds are employed as tracers in Positron Emission Tomography (PET), which is a powerful non-invasive imaging method in medical diagnostics. LÄS MER
3. Synthesis of Organofluorine Compounds and Allenylboronic Acids - Applications Including Fluorine-18 Labelling
Sammanfattning : This work is focused on two areas: the chemistry of organofluorine and organoboron compounds. In the first chapter, a copper-catalysed synthesis of tri- and tetrasubstituted allenylboronic acids is presented. Extension of the same method leads to allenylboronic esters. LÄS MER
4. Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors : Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide
Sammanfattning : This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C.Two methods for the synthesis of 11C-labelled acrylamides have been explored. LÄS MER
5. Tumour Targeting using Radiolabelled Affibody Molecules : Influence of Labelling Chemistry
Sammanfattning : Affibody molecules are promising candidates for targeted radionuclide-based imaging and therapy applications. Optimisation of targeting properties would permit the in vivo visualization of cancer-specific surface receptors with high contrast. In therapy, this may increase the ratio of radioactivity uptake between tumour and normal tissues. LÄS MER