Sökning: "kupffer cells"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden kupffer cells.

  1. 1. Biliary epithelial cells, the immune system and PSC pathogenesis

    Författare :Lena Berglin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary sclerosing cholangitis (PSC) is a chronic, inflammatory liver disease that leads to destruction of the bile duct system. PSC is strongly associated with inflammatory bowel disease, and PSC patients have an increased risk of developing malignancies, especially cholangiocarcinoma (CCA). LÄS MER

  3. 2. The role of liver myeloid cells in obesity and metabolic disease

    Författare :Emelie Barreby; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Macrophages are tissue resident cells with diverse phenotypes and functions depending on their origin, localization and physiological context. In the liver, their main functions are to detoxify the blood from pathogens, debris and metabolic waste arriving to the liver through the systemic and portal circulation. LÄS MER

  4. 3. Proteomic and Functional Analysis of In Vitro Systems for Studies of Drug Disposition in the Human Small Intestine and Liver

    Författare :Magnus Ölander; Per Artursson; Pär Matsson; Edward L. LeCluyse; Volker Lauschke; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proteomics; drug disposition; ADMET; drug transport; drug metabolism; hepatotoxicity; small intestine; liver; caco-2; human hepatocytes; cryopreservation; apoptosis; liver zonation; non-parenchymal cells; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : To reach the bloodstream, an orally administered drug must be absorbed through the small intestine and avoid extensive clearance in the liver. Estimating these parameters in vitro is therefore important in drug discovery and development. LÄS MER

  5. 4. Fat metabolism during total parenteral nutrition: A biochemical and ultra-structural study

    Författare :Bengt Roth; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology; Intravenous Fat Emulsion - Lipid Metabolism - Lipoprotein lipase - Kupffer cells - - Histology - Fatty liver - Adverse reactions - Haemophagocytosis; intensive care; Anestesiologi; intensivvård;

    Sammanfattning : This thesis evaluates alterations in lipid metabolism and Kupffer cell morphology seen during total parenteral nutrition in healthy rats. During infusion of lipid emulsions, cholesterol and phospholipids accumulated in non-high density lipoproteins, while high density lipoproteins were enriched in triglycerides. LÄS MER

  7. 5. Elimination of circulation IgA and IgS immune complexes : An experimental study in mice, rats and guinea pigs

    Författare :Anders Johansson; Ann Kari Lefvert; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Immune complexes were formed between dinitrophenyl- (DNP-) conjugated human serum albumin (HSA) and anti-DNP antibodies (monoclonal mouse IgA or polyclonal rabbit IgG). Blood clearance and tissue distribution of intravenously injected labelled antigen and immunecomplex preparations were studied in mice, rats and guinea pigs. LÄS MER