Sökning: "known and"

Visar resultat 1 - 5 av 9157 avhandlingar innehållade orden known and.

  1. 1. Free energy calculations of G protein-coupled receptor modulation : New methods and applications

    Författare :Willem Jespers; Hugo Gutiérrez-de-Terán; Johan Åqvist; Jonathan Essex; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptor; adenosine receptor; molecular dynamics; free energy perturbation; homology modeling; computer simulations; conformational selectivity; binding free energy.; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : G protein-coupled receptors (GPCRs) are membrane proteins that transduce the signals of extracellular ligands, such as hormones, neurotransmitters and metabolites, through an intracellular response via G proteins. They are abundant in human physiology and approximately 34% of the marketed drugs target a GPCR. LÄS MER

  3. 2. Additive-Driven Improvements in Interfacial Properties and Processing of TMP-Polymer Composites

    Författare :Seyedehsan Hosseini; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; molybdenum disulfide; magnesium stearate; thermomechanical pulp; alkyl ketene dimer; friction; rheology;

    Sammanfattning : Efforts to address environmental concerns have resulted in new regulations designed to plan the reduction of plastic and synthetic polymer usage, necessitating the search for sustainable natural alternatives with comparable cost-effectiveness and mechanical performance. Thermomechanical pulp (TMP) fibres are one of the most affordable natural fibres that have no chemical refining in production, production have a high yield of 90-98% and TMP fibres have been demonstrated to improve the mechanical characteristics (strength, stiffness and toughness) of wood-polymer composites (WPCs) compared to the pure polymer. LÄS MER

  4. 3. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

    Författare :Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. LÄS MER

  5. 4. Shear Fracture and Delamination in Packaging Materials : A study of Experimental Methods and Simulation Techniques

    Författare :Md. Shafiqul Islam; Sharon Kao-Walter; Christian Johansson; Johan Tryding; Blekinge Institute of Technology; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Package opening; Shear test specimen; Stress intensity factor; Finite Element simulation; Scanning electron microscopy; Polymers; Interlaminar shear delamination;

    Sammanfattning : Packages are the means of preservation, distribution and convenience of use for food, medicine and other consumer products. Package opening is becoming complicated in many cases because of cutting cost in design and production of opening techniques. LÄS MER

  7. 5. Walking the Plank of the Entrepreneurial University : The little spin-out that could?

    Författare :Nina Fowler; David Sköld; Marcus Lindahl; Malin Brännback; Uppsala universitet; []
    Nyckelord :University spinouts; research; academic capitalism; entrepreneurship; commercialisation; social forces; Engineering Science with specialization in industrial engineering and management; Teknisk fysik med inriktning mot industriell teknik;

    Sammanfattning : Creating spinout companies (USOs) from university research is one focus of innovation policy. The phenomenon features in two main fields of enquiry: academic entrepreneurship studies, and literature on academic capitalism and the entrepreneurial university. LÄS MER