Sökning: "knockout mice"

Visar resultat 11 - 15 av 285 avhandlingar innehållade orden knockout mice.

  1. 11. Dissecting Phenotypic Variation in Pigmentation using Forward and Reverse Genetics

    Författare :Anders R Hellström; Uppsala universitet; []
    Nyckelord :Pigmentation; eumelanin; pheomelanin; knockout; Silver; SLC45A2; PMEL17; Sex-linked barring; CDKN2A; CDKN2B; ARF; chicken; Japanese quail; MEDICINE; MEDICIN; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Coat color and patterning phenotypes have been extensively studied as a model for advancing our understanding of the relationship between genetic and phenotypic variation. In this thesis, genes of relevance for pigment cell biology were investigated. The dissertation is divided in two parts. LÄS MER

  3. 12. The Role of Hepatic Leukemia Factor in Hematopoiesis

    Författare :Karolina Komorowska; Avdelningen för molekylärmedicin och genterapi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; Hematopoietic Stem Cells; knockout mice; HLF; Transcription Factor; aging;

    Sammanfattning : The development of therapeutic methods based on stem cells (e.g. cell therapy, activating regeneration and organ transplantation), known as regenerative medicine, is still a novel area in the field of life sciences. LÄS MER

  4. 13. Cardiovascular role of PDGF-B in development and disease. Studies in genetically engineered mice

    Författare :Henrik Nyström; Göteborgs universitet; []
    Nyckelord :atherosclerosis; cardiovascular disease; cell retention; in vivo physiology; neointimal hyperplasia; PDGF; transgenic mice; vascular function; vascular smooth muscle cell;

    Sammanfattning : Platelet-derived growth factor B (PDGF-B) is vital for microvascular development, and retention of PDGF-B to extracellular matrix (ECM) is important in this process. However, the role and source of PDGF-B in development of macrovascular function is disputed. LÄS MER

  5. 14. Nuclear receptor functions in the central nervous system : clues from knockout mice

    Författare :Sandra Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Estrogen receptor; liver X receptor; 5alpha-androstane-3beta; 17beta-diol; brain development; neuronal degeneration; spinal cord; motor neuron.;

    Sammanfattning : The nuclear receptor (NR) superfamily is the largest known family of transcription factors in eukaryotes. In the 1980 s when the size of the NR family and the scope of the functions of its members were being discovered, tissue distribution studies revealed that the mRNAs of many of these receptors were expressed in the central nervous system. LÄS MER

  7. 15. Characterization of Centrally Expressed Solute Carriers : Histological and Functional Studies with Transgenic Mice

    Författare :Sahar Roshanbin; Robert Fredriksson; David Engblom; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SLC; Solute carriers; Amino acid transporter; PAT; B0AT2; mTORC1; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The Solute Carrier (SLC) superfamily is the largest group of membrane-bound transporters, currently with 456 transporters in 52 families. Much remains unknown about the tissue distribution and function of many of these transporters. LÄS MER