Sökning: "knock out mice"

Visar resultat 1 - 5 av 87 avhandlingar innehållade orden knock out mice.

1. 1. Knock Knock Knock, Who is there? - Cell Crosstalk within the Bone Marrow

   Författare :Jenny Stjernberg (Zetterblad); Mikael Sigvardsson; Jan-Ingvar Jönsson; Hanna Mikkola; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : This thesis is focused on the subject of cell-cell interaction. Our body is composed of cells, most of them are integrated in a network with other cells that together forms tissues and organs. Every cell type in these complex organs has its special task and location. LÄS MER

3. 2. LXR and aromatase knock-out mice : animal models providing insight into human diseases

   Författare :Hyun-Jin Kim; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : In our characterization of mouse strains carrying mutations in nuclear receptor and aromatase genes we have found phenotypes which resemble four human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome (SS), amyotrophic lateral sclerosis (ALS), and exocrine pancreatic insufficiency. The work in this thesis was designed to understand the roles of LXRalpha, LXRbeta and aromatase in development of these diseases and to investigate whether these animal models help us (1) to understand the etiology of the corresponding human diseases and (2) to develop new therapeutic approaches for the treatment of these diseases. LÄS MER

4. 3. Cardiovascular effects of growth hormone. Studies in genetically engineered mice

   Författare :Irene Andersson; Göteborgs universitet; []
   Nyckelord :acromegaly; autonomic nervous system; cardiovascular disease; cardiac function; vascular function; growth hormone; heart rate variability; hypertension; insulin-like growth factor-1; transgenic mice;

   Sammanfattning : The general aim of this thesis was to enhance the understanding on the relationships between growth hormone (GH) and cardiovascular disease using genetically engineered mice. More specifically the effects of GH on blood pressure (BP), vascular and cardiac function, atherosclerosis and autonomic control of heart rate were studied. LÄS MER

5. 4. Melatonin receptors in pancreatic islets - Linking a genetic variant to functional phenotype

   Författare :Cecilia Nagorny; Diabetes - molekylär metabolism; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melatonin receptor; knock out mice; IVGTT; OGTT; ITT; Hyperinsulinemic clamp; MTNR1B; MT2;

   Sammanfattning : Defective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. LÄS MER

7. 5. Development and validation of a localized murine candidiasis model : The pathogenesis, chemotheraphy and defense mechanisms to Candida mastitis in the lactating mouse

   Författare :Faisal Abdi Guhad; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Murine model; Candida albicans; Pathogenesis; Virulence factors; Amphotericin B; Fluconazole; Complement activation; C3c; SCID mice; Nude mice; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

   Sammanfattning : A murine model of localized candidiasis (mastitis) was developed. The model was analyzed withrespect to its discriminative abilities through investigation of the virulence properties of C.albicans mutant strains compared with the wild-type parental strain. LÄS MER