Sökning: "keratinization"

Hittade 5 avhandlingar innehållade ordet keratinization.

  1. 1. Studies on the pH gradient in normal and ichthyotic human skin

    Författare :Hans Öhman; Linköpings universitet; []
    Nyckelord :keratinization; hyperkeratosis; desquamation; filaggrin; cholesterolsulfate; tape stripping; MEDICINE; MEDICIN;

    Sammanfattning : In search for pathogenetic mechanisms underlying hyperkeratosis, we examined the pH gradient across the stratum corneum in normal and ichthyotic skin. Twenty students and employees, (12 men and 8 womenaged 25-69 years) served as controls. Patients with ichthyoses were recruited from the outpatient clinic (13 men aged 12-71 years). LÄS MER

  3. 2. Vitamin A in normal and diseased human skin : a quantitative study of retinoids and carotenoids with particular reference to disorders of keratinization

    Författare :Ola Rollman; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 3. Genetic studies of skin barrier defects with focus on atopic dermatitis

    Författare :Mårten Winge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atopic dermatitis (AD) is a common, complex inflammatory skin disorder where a defect skin barrier is central in the pathogenesis. Mutations in the filaggrin gene cause ichthyosis vulgaris (IV). IV is one of several keratinization disorders named ichthyoses where mutations in skin barrier genes are a common underlying genetic factor. LÄS MER

  5. 4. Psoriasis : from transcriptome to miRNA function and biomarkers

    Författare :Lorenzo Pasquali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Psoriasis is a chronic inflammatory, immune-mediated skin condition that affects in average 2 to 3% of the world population, phenotypically characterized by red and scaly plaques on the skin of affected patients. It is a multifactorial disorder, in which both genetic predisposition and environment play key roles. LÄS MER

  7. 5. Harm and harm reduction in smokeless tobacco users. An in vitro and clinical study

    Författare :Mats Wallström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cessation; nicotine replacement; smokeless tobacco; immunotoxicity; oral mucosa; snuff; reversibility; Langerhans cells; rat oral epithelium; nicotine;

    Sammanfattning : Background: This thesis describes the effects of smokeless tobacco (ST) and its derivatives on the oral mucosa; the development of, and results of applying a cessation program for snuff users with long and extensive exposure; and the persistent clinical and histomorphological changes after cessation. Methods: Three of the studies were open prospective non-randomized clinical intervention trials using nicotine replacement therapy (NRT) of either 4 mg nicotine chewing gum or 2 mg nicotine lozenges. LÄS MER