Sökning: "keratin filaments"

Hittade 4 avhandlingar innehållade orden keratin filaments.

  1. 1. Skin hydration - How water and osmolytes influence biophysical properties of stratum corneum

    Författare :Sebastian Björklund; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stratum corneum; diffusive transport; permeability; flow-through cell; Franz cell; transdermal drug delivery; water activity; vapor pressure; osmotic gradient; relative humidity; ceramide; free fatty acid; cholesterol; keratin filaments; natural moisturizing factor NMF ; urea; glycerol; molecular mobility; 13C natural-abundance solid-state NMR; polarization transfer; isothermal calorimetry; impedance spectroscopy; X-ray diffraction;

    Sammanfattning : The outermost layer of skin (i.e., the stratum corneum, SC) is the interface that separates the water-rich inside of the body from the relatively dry external environment. SC forms an effective permeability barrier, which has to be overcome in transdermal drug delivery. LÄS MER

  3. 2. Foreign molecules in biomembranes : Molecular effects on intact stratum corneum and model lipid systems

    Författare :Quoc Dat Pham; Fysikalisk kemi; []
    Nyckelord :stratum corneum; lipid; keratin filament; protein; DMPC; penetration enhancer; osmolyte; solvent; monoterpene; fatty acid; hydration; molecular mobility; fluidity; permeability; PT ssNMR; diffusion cell;

    Sammanfattning : This thesis mainly explores how the molecular mobility of lipid and protein components in the outermost layer of the skin, the stratum corneum (SC), varies with different conditions and upon adding foreign compounds. These studies require methods that makes it possible to detect and characterize the minor amount of fluid components in the highly ordered solid SC sample with resolved molecular information. LÄS MER

  4. 3. Human cytokeratins : their use as targets in cancer management

    Författare :Birgitta Sundström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cytokeratins, biochemically related to intermediate filaments (IF), form an intracellular network of filaments which contributes to the mechanical stabilizing of the cell. 19 individual polypeptides, divided into two groups, constitute the cytokeratin family. LÄS MER

  5. 4. Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance

    Författare :Ylva Rosengardten; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hutchinson-Gilford progeria syndrome (HGPS) is a very rare genetic disease that presents some features of accelerated aging. Children with the disease are born appearing healthy but start to develop signs of the disease within their first years of life. LÄS MER