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  1. 1. Telomere length - inheritance pattern and role as a biomarker

    Författare :Katarina Nordfjäll; Göran Roos; Thomas von Zglinicki; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; telomere length; peripheral blood; inheritance; breast cancer; survival; polymorphism; Medical cell biology; Medicinsk cellbiologi;

    Sammanfattning : Telomeres are repetitive TTAGGG structures ending each chromosome and thereby protecting its integrity. Due to the end-replication problem, telomeres shorten with each cell division. When reaching a critical telomere length (TL), the cells stop dividing and enter replicative senescence. LÄS MER