Sökning: "kallikrein-related peptidase"

Hittade 3 avhandlingar innehållade orden kallikrein-related peptidase.

  1. 1. Kallikrein-related peptidases in human epidermis : studies on activity, regulation, and function

    Författare :Kristina Stefansson; Torbjörn Egelrud; Maria Brattsand; Mona Ståhle; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; desquamation; epidermis; stratum corneum; kallikrein-related peptidase; KLK; serine protease inhibitors; Dermatology and venerology; Dermatologi och venerologi;

    Sammanfattning : Introduction. The outermost layer of the epidermis, the stratum corneum (SC), plays a fundamental role in our defense against microorganisms, chemicals, and dehydration. The SC is composed of tightly packed keratinized skin cells, corneocytes. For a functioning skin it is essential that corneocytes are constantly shed (desquamated). LÄS MER

  3. 2. Radioimmunoimaging and Radioimmunotherapy of Prostate Cancer Preclinical evaluation of kallikrein related peptidase 2 targeting

    Författare :Oskar Vilhelmsson Timmermand; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radioimmunoimaging; radioimmunotherapy; antibody; 11B6; indium-111; lutetium-177; kallikrein related peptidase 2; hK2; PSA; prostate cancer; SPECT; KLK2; cherenkov luminescence imaging; CLI;

    Sammanfattning : Prostate cancer is one of the major causes of cancer related deaths in men in Europe and the United States. In this doctoral thesis, radioimmunoimaging and -therapy of prostate cancer was investigated pre-clinically by targeting the human kallikrein-related peptidase 2 (hK2) with radiolabelled monoclonal antibodies. LÄS MER

  4. 3. Clinical investigation and application of Artificial Intelligence in diagnosis and prognosis of squamous cell carcinoma of the head and neck

    Författare :Amir M. Salehi; Karin Nylander; Lena Norberg-Spaak; Wojciech Golusinski; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SCCHN; SCCOT; Recurrence; ML; PET CT; mRNA; transcriptomic; proteomic; Diabetes; AI; Oto-Rhino-Laryngology; oto-rhino-laryngologi;

    Sammanfattning : Background: In Sweden around 1400 people are affected by head and neck cancer each year, and around 400 of these tumours are located in the mobile tongue (SCCOT). A major problem with these tumours is the high degree of relapse. LÄS MER