Sökning: "jan umeå universitet"

Visar resultat 1 - 5 av 190 avhandlingar innehållade orden jan umeå universitet.

  1. 1. The biology of cognitive decline and reduced survival in Parkinson disease : prognostic factors in a population-based cohort

    Författare :David C Bäckström; Lars Forsgren; Jan Linder; Niklas Lenfeldt; Jan Aasly; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson disease; multiple system atrophy; progressive supranuclear palsy; natural history; cognitive impairment; dementia; predictors of mortality; cerebrospinal fluid biomarkers; prospective; population-based; Neurology; neurologi;

    Sammanfattning : Parkinson disease (PD) is a progressive neurodegenerative disease that affects about 1% of the population over 60 years. The cardinal symptoms are motor disabilities but cognitive decline is also common. About 50% of all persons with PD develop dementia within 10 years after disease onset. LÄS MER

  3. 2. NMR as a tool in drug research : Structure elucidation of peptidomimetics and pilicide-chaperone complexes

    Författare :Mattias Hedenström; Jan Jan Kihlberg; Ingmar Sethson; Michael P. Williamson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; NMR; structure calculations; peptidomimetics; desmopressin; Leu-enkephalin; chemical shift mapping; pilicides; chaperones; urinary tract infections.; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : In the last decades NMR spectroscopy has become an invaluable tool both in academic research and in the pharmaceutical industry. This thesis describes applications of NMR spectroscopy in biomedicinal research for structure elucidation of biologically active peptides and peptidomimetics as well as in studies of ligand-protein interactions. LÄS MER

  4. 3. Synthesis of Potential Inhibitors Against HIV

    Författare :Johanna Wachtmeister; Jan Kihlberg; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis describes the syntheses of various potential inhibitors of HIV, e.g. some 3´-hydroxymethyl-substituted carbocyclic nucleoside analogues as reverse transcriptase inhibitors and some symmetry-based peptidomimetics as protease inhibitors. LÄS MER

  5. 4. Till invånarnas tjänst : om marknadsorientering i kommuner

    Författare :Jan-Erik Jaensson; Tomas Müllern; Umeå universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES;

    Sammanfattning : .... LÄS MER

  7. 5. Benign epilepsy of children with centro-temporal EEG foci : clinical, genetic and neurophysiological studies

    Författare :Jan Heijbel; Sigfrid Blom; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : .... LÄS MER