Sökning: "isotype switch"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden isotype switch.

  1. 1. Immunoglobulin isotype switching in health and disease

    Författare :Berivan Baskin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Immunoglobulin isotype switching is the process where the Cmy region, initially located downstream of the VDJ region is replaced by another constant region gene. Class switch recombination takes place between switch (S) regions, composed of tandem repeats of short unit sequences, located 5 of each CH gene, except for Cdelta. LÄS MER

  3. 2. Immunoregulatory differences between adult onset type 1 diabetes and latent autoimmune diabetes in adults (LADA)

    Författare :Magnus Hillman; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endokrinologi; sekretion; diabetologi; diabetology; secreting systems; Isotype class switch; Endocrinology; LADA; Autoantibodies; Autoimmunity; Type 1 diabetes;

    Sammanfattning : Autoimmune diabetes is characterized by cell mediated autoimmunity against insulin producing beta cells in pancreatic islets. Type 1 diabetes is the major cause of diabetes in children and adolescents and is believed to be mediated by a Thl driven destruction of beta cells. LÄS MER

  4. 3. Regulation of Immunoglobulin Isotype Switching and of the Germinal Center Response

    Författare :Minghui He; Eva Severinson; Jayanta Chaudhuri; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; immunologi; Immunology;

    Sammanfattning : After stimulation, B cells can undergo two types of genetic alteration in their immunoglobulin (Ig) genes: somatic hypermutation and class switch recombination (CSR), both of which are initiated by activation-induced cytidine deaminase (AID).Although class switching requires cell proliferation, the mechanism is partly unknown. LÄS MER

  5. 4. Regulation of IgG subclass switching in human B cells

    Författare :Qiang Pan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human IgG can be subdivided into four subclasses, each encoded by a separate heavy chain constant (CH) region gene and endowed with unique biological and functional properties. Deficiencies of single or multiple IgG subclasses have been suggested to be associated with increased susceptibility to recurrent infections in humans. LÄS MER

  7. 5. The acidic domain, the human version and the protein interaction of the ETS transcription factor SPI-C

    Författare :Robert Carlsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; transplantation; Immunologi; serologi; Immunology; B-lymphocyte; phylogeny; STAT6; SPI-C; transcription;

    Sammanfattning : Primary infections and vaccination stimulates the immunesystem to produce memory cells that rapidly respond to reexposure of the same antigen. These memory responses are dependent on an adaptive type of immunity that sustains the reactivity of the immune system by long-lived memory immune cells. LÄS MER