Sökning: "islet transplantation"
Visar resultat 11 - 15 av 69 avhandlingar innehållade orden islet transplantation.
11. The Microvasculature of Endogenous and Transplanted Pancreatic Islets : Blood Perfusion, Oxygenation and Islet Endocrine Function
Sammanfattning : Type 1 diabetes mellitus affects millions of people worldwide. Islet transplantation is a minimal invasive surgical procedure that restores euglycemia and halts the progression of diabetic complications. However, despite transplantation of islets from multiple donors most patients reverse to hyperglycemia within five years. LÄS MER
12. Studies of Innate and Adaptive Immunity in Islet Transplantation
Sammanfattning : Clinical islet transplantation is today an established alternative treatment for a selected group of type 1 diabetes patients. The predominant technique for transplantation is infusion of islets in the liver via the portal vein. LÄS MER
13. Studies of Regulatory T cells with Implications for Clinical Applications
Sammanfattning : Regulatory T cells (Tregs) are vital for regulating immune homeostasis and for preventing immunopathology. The immunosuppressive functions of Tregs have raised hope for their potential use in clinical applications. LÄS MER
14. Costimulation Blockade in Experimental Transplantation
Sammanfattning : Transplantation is the only cure for end-stage organ failure. With the transplantation follows the need for continuous treatment with immunosuppressive agents for as long as the graft functions, which entails major side effects. Less toxic treatments are therefore in great demand. Preferably, the treatment should also be limited in time. LÄS MER
15. Challenges in Islet Transplantation and Strategies to Improve Beta-Cell Function
Sammanfattning : The incidence of type 1 diabetes is increasing worldwide and therapies of islet transplantation and potential cell-based therapies are rapidly evolving. Choosing the optimal site for such therapies is crucial for safety and for obtaining the best possible outcome. LÄS MER