Sökning: "ionophore"
Visar resultat 1 - 5 av 30 avhandlingar innehållade ordet ionophore.
1. Salinomycin analogs : Mechanistic probes and structure–activity relationships against cancer stem cells
Sammanfattning : Cancer stem cells are a subpopulation of cells that possess an increased tumorigenic potential. Such cells are connected to drug resistance, metastasis, and cancer recurrence. In 2009, the polyether ionophore salinomycin was shown to exhibit selective activity against cancer stem cells. LÄS MER
2. Leukotriene C4 synthesis and export in human platelets and leukocytes : LTC4 synthase expression in normal and leukemic myeloid cells
Sammanfattning : Leukotriene (LT)C4 synthase catalyses conjugation of the unstable epoxide LTA4 with reduced glutathione and is the rate-limiting enzyme in the formation of cysteinyl leukotrienes, powerful mediators of asthma and inflammation. The presence of LTC4 synthase in platelets was demonstrated by purification and characterization of bovine platelet LTC4 synthase. LÄS MER
3. Mechanisms of inflammatory lung injury : Studies in isolated perfused rat lungs
Sammanfattning : Isolated perfused rat lungs (IPRLs) were used to study mechanisms andmediators of lung injury due to (i) ischemia-reperfusion (IR) and (ii) endotoxin. To investigate the role of polymorphonuclear neutrophils (PMNs) in IR injury, PMNs were added to the perfusate of IPRLs subjected to IR. LÄS MER
4. Spectroelectrochemistry with Ultrathin lon-Selective Membranes
Sammanfattning : Rapid and decentralized chemical sensing strategies are highly demanded in contemporary society to monitor ongoing processes relevant to the environment, food analysis, healthcare, sports performance, etc. In this context, ion-selective electrodes (ISEs) based on polymeric membranes have emerged as a promising analytical technique owing to their features of low cost, portability, versatility, and energy efficiency. LÄS MER
5. A novel principle for immunomodulator delivery with hematopoietic cells as vehicles Focus on soluble TNF-receptor gene expression, targeting to secretory lysosomes and regulated secretion
Sammanfattning : The goal of this research is to use hematopoietic cells as vehicles for targeting transgenic immunomodulators to the inflammatory sites. The work presented was focused on the anti-inflammatory soluble TNF receptor. A transmembrane soluble TNF receptor (sTNFR1) construct was expressed in hematopoietic cell lines. LÄS MER