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Visar resultat 1 - 5 av 213 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Ion Tracks for Micro- and Nanofabrication : From Single Channels to Superhydrophobic Surfaces

   Författare :Reimar Spohr; Lars Westerberg; Lars Montelius; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ion track; single ion; real time; phase detection; conductometric cell; conductometry; electro replication; microtechnology; nanotechnology; surfactant; self organization; GMR; magnetic; sensor technology; hydrophobic; tilted texture.; Physics; Fysik; Materialvetenskap; Materials Science;

   Sammanfattning : A method is described for preset-count irradiations between 1 and 100 ions singling-out individual ions from an ion beam with more than a billion ions arriving per second. The ion tracks are etched in a conductometric system with real-time evaluation of the acquired data. The etch process can be interrupted when reaching a preset channel diameter. LÄS MER

3. 2. Modeling of voltage-gated ion channels

   Författare :Pär Bjelkmar; Erik Lindahl; Toby W. Allen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular modeling; Molecular dynamics; Voltage-gating; Ion channels; Protein structure prediction; Chemistry; Kemi; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : The recent determination of several crystal structures of voltage-gated ion channels has catalyzed computational efforts of studying these remarkable molecular machines that are able to conduct ions across biological membranes at extremely high rates without compromising the ion selectivity. Starting from the open crystal structures, we have studied the gating mechanism of these channels by molecular modeling techniques. LÄS MER

4. 3. Structural transitions of proton-gated ion channels : Involving pH sensing, heterogeneity and lipid interactions

   Författare :Urška Rovšnik; Erik Lindahl; Hugues Nury; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ion channels; cryo-electron microscopy; pH gating; simulations; structure-function relationship; GLIC; DeCLIC; biokemi; Biochemistry;

   Sammanfattning : Studying protein structure and function involves analyzing the relationship between a protein's three-dimensional assembly and its dynamic biochemical activity. The superfamily of pentameric ligand-gated ion channels (pLGICs) constitutes a classic yet illuminating experimental system for structure-function studies. LÄS MER

5. 4. Dendritic and axonal ion channels supporting neuronal integration : From pyramidal neurons to peripheral nociceptors

   Författare :Marcus Petersson; Erik Fransén; Theodore Cummins; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channels; computational modeling; simulations; dendrites; axons; TRP; hippocampus; C-fiber nociceptors; pain;

   Sammanfattning : The nervous system, including the brain, is a complex network with billions of complex neurons. Ion channels mediate the electrical signals that neurons use to integrate input and produce appropriate output, and could thus be thought of as key instruments in the neuronal orchestra. LÄS MER

7. 5. Combining low resolution, high resolution, functional, and simulation techniques : In the study of pentameric ligand-gated ion channels

   Författare :Marie Lycksell; Erik Lindahl; Kresten Lindorff-Larsen; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neutrons; Small-angle scattering; Cryo-EM; Simulations; Ion channels; Biophysics; biofysik;

   Sammanfattning : Combining methods yielding different information is a powerful approach for understanding structural biology in general, and in particular systems such as pentameric ligand-gated ion channels (pLGICs). Pentameric ligand-gated ion channels are membrane proteins that sense chemical signals, which they convert to changes in membrane potential. LÄS MER