Sökning: "ion channel receptor"

Visar resultat 16 - 20 av 65 avhandlingar innehållade orden ion channel receptor.

  1. 16. Ion channels in drug discovery : focus on biological assays

    Författare :Kim Dekermendjian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Ion channels; GABAA receptor; sodium channels; TRPM8; drug discovery; high throughput screening assays; FLIPR; automated electrophysiology;

    Sammanfattning : Ion channels are well characterised drug targets. However, the techniques used to study ion channel pharmacology have not been particularly applicable to modern drug discovery. LÄS MER

  3. 17. Beyond AMPA and NMDA: Slow synaptic mGlu/TRPC currents : Implications for dendritic integration

    Författare :Marcus Petersson; Erik Fransén; Abdel El Manira; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transient receptor potential; TRP; metabotropic glutamate receptor; mGlu1 5; dendritic integration; synaptic activation; temporal summation; low-frequency; entorhinal cortex; mathematical model; computational neuroscience; Computer science; Datavetenskap;

    Sammanfattning : In order to understand how the brain functions, under normal as well as pathological conditions, it is important to study the mechanisms underlying information integration. Depending on the nature of an input arriving at a synapse, different strategies may be used by the neuron to integrate and respond to the input. LÄS MER

  4. 18. Ion homeostasis in control of stem cell proliferation

    Författare :Shaimaa Abdelhady; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ion homeostasis is critically maintained in all cells by a combined effort from various ion channels, transporters, pumps, and gap junctions. Ion fluxes are essential in excitable cells as they regulate the excitability of the cells and initiate and propagate action potentials. LÄS MER

  5. 19. The GABAA Receptor as Target for Novel Heterocyclic Compounds

    Författare :Jakob Nilsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Ligands for the benzodiazepine-binding site of the GABAA receptor can belong to structurally diverse classes of compounds including, in spite of the name of the binding site, many non-benzodiazepine structures. The GABAA receptor is a ligand-gated ion channel assembled of five subunits from eight different classes with multiple isoforms. LÄS MER

  7. 20. Exploring Ligand Binding in HIV-1 Protease and K+ Channels Using Computational Methods

    Författare :Fredrik Österberg; Johan Åqvist; Olle Edholm; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; hERG; KcsA; AutoDock; LIE; molecular dynamics; ion channels; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : Understanding protein-ligand interactions is highly important in drug development. In the present work the objective is to comprehend the link between structure and function using molecular modelling. LÄS MER