Sökning: "iodofluorination"

Hittade 2 avhandlingar innehållade ordet iodofluorination.

  1. 1. Novel Applications of Benziodoxole Reagents in the Synthesis of Organofluorine Compounds

    Författare :Nadia O. Ilchenko; Kálmán J. Szabó; Cristina Nevado; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; trifluoromethylation; hypervalent iodine; Togni reagent; difluorination; iodofluorination; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis concerns method development of new synthetic routes by applying electrophilic hypervalent iodine reagents, such as trifluoromethyl-benziodoxole (Togni reagent) and fluoro-benziodoxole. The first project involved the addition of an oxygen moiety and trifluoromethyl group across double and triple bonds (both groups derived from the hypervalent iodine reagent). LÄS MER

  3. 2. Development of new Fluorination Methods Directed to Fluorine-18 Labelling

    Författare :Miguel Ángel Cortés González; Kálmán J. Szabó; Guosheng Liu; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fluorine; fluorine-18; late-stage; labelling; nucleophilic; electrophilic; fluorination; positron emision tomography; PET; hypervalent iodine; benziodoxole; metal-free; DBU; copper; palladium; rhodium; carbene; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis deals with the development of new fluorination reactions and their application to fluorine-18 labelling. Fluorine-18 labelled compounds are employed as tracers in Positron Emission Tomography (PET), which is a powerful non-invasive imaging method in medical diagnostics. LÄS MER