Sökning: "intrinsic enrichment"

Visar resultat 6 - 10 av 12 avhandlingar innehållade orden intrinsic enrichment.

  1. 6. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization

    Författare :Nicklas Österlund; Astrid Gräslund; Leopold L. Ilag; Mikael Oliveberg; Sheena E. Radford; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein aggregation; amyloid-β; neurodegeneration; Alzheimer’s disease; chaperones; DnaJ; biomembranes; native mass spectrometry; Biophysics; biofysik;

    Sammanfattning : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. LÄS MER

  3. 7. Resolving developing neuronal lineages in the ventral midbrain

    Författare :Nigel Kee; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The numerous cells and cell types of our bodies originate from a fertilised egg. Through the study of the developing embryo, we have come to understand much about how different cells in different tissues arise from this single cell, and how they are related to one another within an expansive family tree. LÄS MER

  4. 8. Assessment of pancreatic islet cell function and survival

    Författare :Martin Köhler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Function and survival of pancreatic islet insulin-producing beta-cells (β-cells) and glucagonproducing alpha-cells (α-cells) were studied, and methods for this purpose were developed or refined. Dynamic control of glucose metabolism is essential for β-cell stimulus-secretion coupling. LÄS MER

  5. 9. Deciphering microglia plasticity in glioma

    Författare :Dalel Saidi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Microglia are the innate immune cells of the brain. One of the main characteristics of microglia is its extremely plasticity, which is necessary for them to deal with changing circumstances. Activation of microglia can contribute to contrasting effects by either proinflammatory, anti-inflammatory, or tumor-supportive phenotypes. LÄS MER

  7. 10. Multiscale modeling of atomic transport phenomena in ferritic steels

    Författare :Luca Messina; Pär Olsson; Nils Sandberg; Pål Efsing; Pascal Bellon; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; diffusion; impurities; iron; metals; kinetic Monte Carlo; ab initio; mean field; defects; embrittlement; reactor pressure vessel; neural networks; Fysik; Physics;

    Sammanfattning : Defect-driven transport of impurities plays a key role in the microstructure evolution of alloys, and has a great impact on the mechanical properties at the macroscopic scale. This phenomenon is greatly enhanced in irradiated materials because of the large amount of radiation-induced crystal defects (vacancies and interstitials). LÄS MER