Sökning: "intravital microscopy"

Visar resultat 11 - 15 av 31 avhandlingar innehållade orden intravital microscopy.

  1. 11. In vivo imaging of leukocyte-endothelium interactions in septic lung injury

    Författare :Jonas Roller; Kirurgi; []
    Nyckelord :Sepsis; Acute lung injury; Leukocyte recruitment; Intravital fluorescence microscopy;

    Sammanfattning : Excessive accumulation of leukocytes in the lung represents a key feature in the development of an acute lung injury (ALI). Numerous studies demonstrated that leukocyte rolling is a compulsory precondition for the firm adhesion in organs. However, it seems that the recruitment process of leukocytes in the lung is more complex. LÄS MER

  3. 12. Role of mast cell-derived mediators for leukocyte / endothelium-interactions and microvascular mechanisms in inflammation and in anaphylaxis

    Författare :Yancai Guo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Anaphylaxis; histamine; intravital microscopy; leukocyte; mast cell-deficient rat Ws Ws ; microdialysis;

    Sammanfattning : The overall objective of this thesis was to study the roles of mast cell-derived mediators for leukocyte/endothelium interactions and microvascular mechanisms in inflammation and in anaphylaxis, using mast cell-deficient Ws/Ws rats and their wild-type +/+ littermates. The efflux of endogenous histamine and edema formation evoked by subplantar injection of compound 48/80 in rat hind-paws was dose-dependent in +/+ rats, and was essentially lacking in Ws/Ws rats. LÄS MER

  4. 13. Acid transport through gastric mucus : A study in vivo in rats and mice

    Författare :Mia Phillipson; Lena Holm; Henrik Sjövall; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; gastric acid; pH-sensitive microelectrode; mucus; mucosal blood flow; nitric oxide; intravital microscopy; laser Doppler flowmetry; Fysiologi; Physiology; Fysiologi; Physiology; fysiologi;

    Sammanfattning : The gastric mucosa is frequently exposed to endogenously secreted hydrochloric acid of high acidity. Gastric mucosal defense mechanisms are arranged at different levels of the gastric mucosa and must work in unison to maintain its integrity. LÄS MER

  5. 14. Functions of integrin receptors in extravascular neutrophil migration and respiratory burst

    Författare :Joachim Werr; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adhesion molecules; leukocyte migration; neutrophils; chemotaxis; integrins; respiratory burst; leukocyte extravasation; extracellular matrix; intravital microscopy; acute inflammation;

    Sammanfattning : Leukocytes circulate in the vasculature, but, must leave the blood stream and migrate through the surrounding tissue to exert their protective functions in inflammation. Numerous studies have revealed that intravascular leukocyte-endothelial cell interactions involve functions of adhesion molecules belonging to the selectin and integrin receptor families. LÄS MER

  7. 15. Mediator synergism in mast celldependent inflammation : role of histamine for leukocyte recruitment

    Författare :Henrik Thorlacius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Chemoattractants; dexamethasone; histamine; inflammation; intravital microscopy; mast cells; leukocyte adhesion; leukocyte rolling; microcirculation; mast cells; nitric oxide; leukotrienes; P-selectin.;

    Sammanfattning : The aim of the present thesis was to study functional interactions between histamine and chemotactic mediators, and the role of histamine for leukocyte recruitment in mast cell-dependent inflammation. Leukocyte rolling, adhesion and emigration. LÄS MER