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Visar resultat 1 - 5 av 18 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Aspects of Postoperative Pain Relief with Special Emphasis on Epidural Analgesia and Major Non-Cardiac Surgery

   Författare :Per Flisberg; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intensivvård; intensive care; Anaesthesiology; respiratory depression.; adverse effects; intravenous morphine; thoracic epidural; : Postoperative pain; long-term treatment; Anestesiologi;

   Sammanfattning : Postoperative pain relief with opioids after major non-cardiac surgery may give rise to adverse effects. The fear of dangerous side effects may therefore limit the optimal use of different treatment modalities in surgical wards. LÄS MER

3. 2. Microdialysis and Intensive Care. Clinical and experimental studies

   Författare :Per Ederoth; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Anaesthesiology; traumatic brain injury; glucose; glycerol; lipolysis; epidural; postoperative analgesia; experimental pancreatitis; human; blood-brain barrier; morphine; pharmacokinetics; Microdialysis; intensive care; Anestesiologi; intensivvård;

   Sammanfattning : Microdialysis was used to monitor local concentrations of energy metabolites in different organs, and to study the pharmacokinetics of morphine over the blood-brain barrier in intact and injured brain tissue in conditions treated in the Intensive Care Unit. After major abdominal or thoracoabdominal surgery, postoperative thoracic epidural analgesia resulted in higher glycerol concentrations in the deltoid subcutaneous adipose tissue, implying increased lipolysis, on the third postoperative day as compared to intravenous infusion of morphine, possibly due to a locally increased sympathetic tone. LÄS MER

4. 3. Intravenous morphine after gynecological surgery : pain relief, endocrine and immune respone

   Författare :Marianne Eriksson-Mjöberg; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Anaesthesia: general; epidural. Postoperative pain: PCA; morphine; bupivacaine. Hormones: adrenocortical steroids; estrogens. Immune response: Interleukin-6.;

   Sammanfattning : Background: We need more efficient methods to alleviate postoperative pain and reduce endocrine / immune stress response. Subjects and methods: Patient controlled analgesia (PCA) with iv morphine was evaluated with respect to pain relief and endocrine / immune response to surgical trauma in 130 patients undergoing gynecological surgery. LÄS MER

5. 4. Pain relief following cesarean section : short and long term perspectives

   Författare :Boel Niklasson; Agneta Blanck; Märta Segerdahl; Susanne Georgsson Öhman; Sophiahemmet Högskola; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain management; Local anesthesia; Cesarean section; Morphine consumption; Postoperative pain; Persistent pain; Risk factors; Quality of daily life; Multimodal treatment; Oxycodone; Codeine; Newborn; Safety; pain management;

   Sammanfattning : BackgroundPostoperative pain treatment in women undergoing cesarean section (CS) needs to be effective to enable fast and smooth recovery without adverse outcomes and to improve breastfeeding and bonding between mother and child. It is also important that pain treatment should have minimal impact on the newborn. LÄS MER

7. 5. On cholecystokinin-opioid interaction in the spinal dorsal horn following peripheral nerve injury and inflammation

   Författare :Guilherme de Araújo Lucas; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cholecystokinin; Cholecystokinin receptors; Morphine; Spinal cord; Axotomy; Inflammation; Peptide release; Morphine tolerance; [my]-opioid receptor; Flexor reflex; Microdialysis;

   Sammanfattning : The peptide cholecystokinin (CCK) antagonizes opioid-induced analgesia. Conversely, antagonists of CCK receptors enhance the analgesic effect of opioids. Together, these results support a role for CCK as an anti-opioid peptide in pain mechanisms. LÄS MER