Sökning: "intratumoral administration"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden intratumoral administration.
1. Intratumoral CD40 stimulating therapy in patients with advanced cancer
Sammanfattning : CD40-CD40L interaction activates DCs to become highly efficient APCs and skews the adaptive immune response towards a Th I phenotype driving cytotoxic T cells, M1 macrophages and natural killer cells. Furthermore, engagement of CD40L to CD40 positive cancer cells can have direct anti-proliferative effects, induce apoptosis and increase expression of MHC and other co-stimulatory molecules, thereby enhancing cancer cell recognition. LÄS MER
2. Immunological aspects of intratumoral chemotherapy and immunotherapy in malignant brain tumors
Sammanfattning : Advances in surgery, chemo- and radiotherapy have only modestly improved survival rates of malignant brain tumor patients during the last decades. Emerging evidence suggests that an efficient treatment of malignant brain tumors will likely require the management of multiple aspects of tumor pathobiology in order to manipulate features as tumor heterogeneity and tumor immunosuppression. LÄS MER
3. Radioimmunotherapy of Metastatic Disease - Studies of Alpha- and Beta-particle-Emitting Radionuclides in a Preclinical Model
Sammanfattning : In radioimmunotherapy, monoclonal antibodies (mAbs) are used as a targeting agent carrying a toxic payload consisting of radionuclides. This treatment allows the irradiation of small lesions, even on the microscopic level. In the present work, two radionuclides with different properties were used. LÄS MER
4. Immunotherapy and COX-2 inhibition against malignant brain tumors
Sammanfattning : Glioblastoma multiforme (GBM) is the most common primary brain tumor in the central nervous system and the prognosis is very poor despite conventional therapies including surgery, chemo- and radiotherapy. Peripheral vaccination with irradiated tumor cells represent a novel therapy that targets both dividing and non-dividing tumor cells and minimizes the risk of therapy resistance by presenting multiple tumor antigens. LÄS MER
5. Novel treatments of glioblastoma in experimental models
Sammanfattning : One of the major problems with malignant brain tumours, such as glioblastoma multiforme, is that despite being able to remove the major bulk of the tumour through surgery and treating the patients with chemotherapy and radiotherapy, we know that tumour cells have already spread throughout the brain. Furthermore, we now know that the glioblastoma cells effectively suppress the patients’ own anti-tumour response. LÄS MER
