Sökning: "intraperitoneal administration"

Visar resultat 1 - 5 av 34 avhandlingar innehållade orden intraperitoneal administration.

  1. 1. Intraperitoneal 5-Fluorouracil treatment of cancer - clinical and experimental studies

    Detta är en avhandling från Umeå : Kirurgisk och perioperativ vetenskap

    Författare :Mikael Öman; Peter Naredi; Larsolof Hafström; Johan Permert; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; intraperitoneal; 5-fluorouracil; pancreas cancer; vasopressin; Xenon-clearance; Kirurgi; MEDICINE Surgery; MEDICIN Kirurgi; Surgery; kirurgi;

    Sammanfattning : Background:Pancreas cancer is a most aggressive malignancy. More than 80% of patients diagnosed with pancreas cancer, exhibit such advanced disease, that curative surgery is impossible. Systemic chemotherapy prolongs survival to 5-9 months. LÄS MER

  2. 2. RADIOIMMUNOTHERAPY & EXTRACORPOREAL ADSORPTION Preclinical Studies of the Pharmacokinetics & Biotinylation of Radioimmunoconjugates in Immunocompetent Rats

    Detta är en avhandling från Medicinsk Informationsteknik, Malmö

    Författare :Zhongmin Wang; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; oncology; cancerology; Cytologi; Cytology; extracorporeal adsorption; tri-functional chelator; maximal tolerable dose; biotin; intraperitoneal administration; biodistribution; pharmacokinetics; biotinylation; radiolabeling; rat; monoclonal antibody; radionuclide;

    Sammanfattning : Extracorporeal adsorption (ECAT) is a novel strategy to reduce activity in whole body (WB), blood and radiosensitive organs by removing the excess of radiolabeled and biotinylated monoclonal antibody (MAb) from blood so that tumor/normal tissue ratio (T/N) could be improved. By increasing T/N, higher amounts of radiolabeled MAb might be administered, making it possible to treat disseminated carcinomas. LÄS MER

  3. 3. Intraperitoneal Chemotherapy of Ovarian Cancer

    Detta är en avhandling från Edsbruk : Akademitryck AB

    Författare :Henric Malmström; Kamma Berthelsen; [1993]

    Sammanfattning : Ovarian cancer is still the most common cause of death among gynecologic malignancies in spite of the fact that newer and more effective drugs and/or administration techniques have been developed in the last decade. However, substantial improvements in response rate andprogression-free survival have been reported in many studies. LÄS MER

  4. 4. A Pharmacokinetic and Pharmacodynamic Rationale for Perioperative Cancer Chemotherapy in Patients with Peritoneal Carcinomatosis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Kurt Van der Speeten; Haile Matheme; Paul Sugarbaker; Lars Pahlman; Ingvar Syk; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peritoneal carcinomatosis; Cytoreductive surgery; Intraperitoneal Chemotherapy; HIPEC; EPIC; Pharmacokinetics; Pharmacodynamics; Morbidity; Mortality; MEDICINE Surgery Surgical research Surgery; MEDICIN Kirurgi Kirurgisk forskning Kirurgi; Kirurgi; Surgery;

    Sammanfattning : Peritoneal carcinomatosis (PC) is a common manifestation of both gastrointestinal and gynecologic malignancies. Until recently, this condition was considered beyond curative intent treatment. Since the 1980s, new treatment strategies combining cytoreductive surgery (CRS) with perioperative intraperitoneal and intravenous chemotherapy have emerged. LÄS MER

  5. 5. Endothelial Barrier Dysfunction in Multiple Organ Injury. An Experimental Study in Rats

    Detta är en avhandling från Department of Surgery, Clinical Sciences Lund, Lund University

    Författare :Xiaoming Deng; [1997]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orthopaedics; Surgery; Endothelial barrier permeability; Multiple organ dysfunction syndrome; Zymosan; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Multiple organ dysfunction syndrome (MODS) is still the leading cause of mortality in the surgical intensive care unit. The effect on among others endothelial barrier permeability, reticuloendothelial function, organ function and protease-antiprotease activities was studied following a variety of challenges, especially over-activation of macrophages induced by intraperitoneal administration of zymosan. LÄS MER