Sökning: "intraperitoneal administration"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden intraperitoneal administration.

1. 1. Intraperitoneal 5-Fluorouracil treatment of cancer - clinical and experimental studies

   Författare :Mikael Öman; Peter Naredi; Larsolof Hafström; Johan Permert; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; intraperitoneal; 5-fluorouracil; pancreas cancer; vasopressin; Xenon-clearance; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

   Sammanfattning : Background:Pancreas cancer is a most aggressive malignancy. More than 80% of patients diagnosed with pancreas cancer, exhibit such advanced disease, that curative surgery is impossible. Systemic chemotherapy prolongs survival to 5-9 months. LÄS MER

3. 2. RADIOIMMUNOTHERAPY & EXTRACORPOREAL ADSORPTION Preclinical Studies of the Pharmacokinetics & Biotinylation of Radioimmunoconjugates in Immunocompetent Rats

   Författare :Zhongmin Wang; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; oncology; cancerology; Cytologi; Cytology; extracorporeal adsorption; tri-functional chelator; maximal tolerable dose; biotin; intraperitoneal administration; biodistribution; pharmacokinetics; biotinylation; radiolabeling; rat; monoclonal antibody; radionuclide;

   Sammanfattning : Extracorporeal adsorption (ECAT) is a novel strategy to reduce activity in whole body (WB), blood and radiosensitive organs by removing the excess of radiolabeled and biotinylated monoclonal antibody (MAb) from blood so that tumor/normal tissue ratio (T/N) could be improved. By increasing T/N, higher amounts of radiolabeled MAb might be administered, making it possible to treat disseminated carcinomas. LÄS MER

4. 3. Intraperitoneal Chemotherapy of Ovarian Cancer

   Författare :Henric Malmström; Kamma Berthelsen; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Ovarian cancer is still the most common cause of death among gynecologic malignancies in spite of the fact that newer and more effective drugs and/or administration techniques have been developed in the last decade. However, substantial improvements in response rate andprogression-free survival have been reported in many studies. LÄS MER

5. 4. A Pharmacokinetic and Pharmacodynamic Rationale for Perioperative Cancer Chemotherapy in Patients with Peritoneal Carcinomatosis

   Författare :Kurt Van der Speeten; Haile Matheme; Paul Sugarbaker; Lars Pahlman; Ingvar Syk; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peritoneal carcinomatosis; Cytoreductive surgery; Intraperitoneal Chemotherapy; HIPEC; EPIC; Pharmacokinetics; Pharmacodynamics; Morbidity; Mortality; Surgery; Kirurgi; Kirurgi; Surgery;

   Sammanfattning : Peritoneal carcinomatosis (PC) is a common manifestation of both gastrointestinal and gynecologic malignancies. Until recently, this condition was considered beyond curative intent treatment. Since the 1980s, new treatment strategies combining cytoreductive surgery (CRS) with perioperative intraperitoneal and intravenous chemotherapy have emerged. LÄS MER

7. 5. Endothelial Barrier Dysfunction in Multiple Organ Injury. An Experimental Study in Rats

   Författare :Xiaoming Deng; Lund Kirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orthopaedics; Surgery; Endothelial barrier permeability; Multiple organ dysfunction syndrome; Zymosan; traumatology; Kirurgi; ortopedi; traumatologi;

   Sammanfattning : Multiple organ dysfunction syndrome (MODS) is still the leading cause of mortality in the surgical intensive care unit. The effect on among others endothelial barrier permeability, reticuloendothelial function, organ function and protease-antiprotease activities was studied following a variety of challenges, especially over-activation of macrophages induced by intraperitoneal administration of zymosan. LÄS MER