Sökning: "intranasal administration"
Visar resultat 1 - 5 av 26 avhandlingar innehållade orden intranasal administration.
1. Intranasal administration of peptides : the effects of formulation and delivery systems on: nasal deposition, biological response and bioavailability of desmopressin
Sammanfattning : .... LÄS MER
2. Models for the Transfer of Drugs from the Nasal Cavity to the Central Nervous System
Sammanfattning : The blood-brain barrier restricts the access of many compounds, including therapeutic agents, to the brain. Several human studies indicate that nasal administration of hydrophilic compounds, such as peptides, can bypass the blood-brain barrier. The aims of this thesis were to develop and refine models for this direct nose-to-brain transfer. LÄS MER
3. Polymer Gels as Pharmaceutical Dosage Forms : Rheological Performance and Physicochemical Interactions at the Gel-Mucus Interface for Formulations Intended for Mucosal Drug Delivery
Sammanfattning : Drug delivery to the nasal and ocular mucosa faces several obstacles. One of these is from the effective clearance mechanisms present in the nose and eye. Polymer gels with suitable rheological properties can facilitate the absorption of poorly absorbed drugs by increasing the contact time of the drug with the mucosa. LÄS MER
4. Pain in pediatric oncology : Diagnostics and treatment
Sammanfattning : Pain treatment is a crucial aspect in the care of children with cancer and several studies demonstrate inefficient pain treatment. The general aims of the thesis were to identify the current pain problems in pediatric oncology, and to see whether specific interventions could improve the situation. LÄS MER
5. Cholera toxin B subunit as a carrier for inducing mucosal immunity and/or peripheral tolerance
Sammanfattning : When an antigen is introduced via a mucosal route, either immunity or tolerance, or even both may be induced. Both immunity and tolerance are actively induced phenomena and both of them could have important medical implications as well as potential prophylactic or therapeutic applications. LÄS MER