Sökning: "intracellular sorting"

Visar resultat 21 - 25 av 30 avhandlingar innehållade orden intracellular sorting.

  1. 21. Functional characterization of the secretory pathway and the role of COPI vesicles

    Författare :Johan Hiding; Göteborgs universitet; []
    Nyckelord :Golgi; Phosphoinositides; Fusion; COPI; ARF1; Proteomics; ER;

    Sammanfattning : In the secretory pathway, proteins synthesized in the endoplasmatic reticulum move through the Golgi apparatus in a cis-to-trans direction and then sorts into different types of vesicles at the trans-Golgi network. How intracellular transport takes place has been the focus of cell biology research for a long time. LÄS MER

  3. 22. Role of tubular scattered cells of the kidney in disease and regeneration

    Författare :Krzysztof Krawczyk; Malmö Klinisk patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney Diseases; acute kidney disease; acute kidney injury; chronic kidney disease; SOX9; pIgR; Polymeric immunoglobulin receptor; Immune cells; papillary carcinoma; pRCC; Kidney cancer;

    Sammanfattning : With well over 700 000 deaths every year worldwide, kidney disease constitutes an immense health problem for patients and society. The total global number of people with kidney disease regardless of severity amounts to a staggering 600 000 000. LÄS MER

  4. 23. Mucins, Cystic Fibrosis and PDZ protein interactions

    Författare :Emily Malmberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucin; PDZ; transmembrane; MUC1; Cystic Fibrosis; clathrin; CFTR; PDZK1; Bcr; endocytosis; MUC17;

    Sammanfattning : Cystic Fibrosis (CF) is caused and characterized by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The dominating feature of the disease is mucus accumulation on mucosal surfaces, but no direct functional connection between mucus and CFTR is known. LÄS MER

  5. 24. Transforming growth factor a in human hematopoietic cells

    Författare :Thomas M. Walz; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : TGF-a, transforming growth factor a, is a potent growth factor belonging to the family of EGF (epidermal growth factor) -related proteins. Binding to the same receptor as EGF it has a ubiquitous repertoire of target cells, including, mesenchymal, epithelial and neuronal cells. LÄS MER

  7. 25. Bacterial genotoxins : an interface between infection and cancer biology

    Författare :Laura Levi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Infections contribute to the development of more than 20% of all malignancies in humans. While strong evidence exists for a number of virus-associated cancers, the role of bacterial infections is still poorly appreciated although there are evidences that link chronic bacterial infections to increased risk of certain tumors. LÄS MER