Sökning: "intracellular sorting"

Visar resultat 16 - 20 av 30 avhandlingar innehållade orden intracellular sorting.

  1. 16. Adseverin – An Immune-Specific Target of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

    Författare :Camilla Svensson; Lars Wärngård; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; 2; 3; 7; 8-Tetrachlorodibenzo-p-dioxin; TCDD; adseverin; aryl hydrocarbon receptor; immunotoxicity; thymus; cytoskeleton; Toxikologi; Toxicology; Toxikologi; Toxicology; toxikologi;

    Sammanfattning : The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces thymus atrophy and immunosuppression in all animal species examined and these effects constitute a potential risk to humans. TCDD can via binding to the intracellular aryl hydrocarbon receptor (AhR), modulate transcription of a number of genes and the aim of this thesis has been to identify such genes, which may explain the mechanisms behind TCDD-mediated immunotoxicity. LÄS MER

  3. 17. Rational and combinatorial genetic engineering approaches for improved recombinant protein production and purification

    Författare :Nina Bandmann; Per-Åke Nygren; Helena Berglund; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Aqueous two-phase system; combinatorial library; expression vector; flow cytometry; fusion tag; partitioning; peptide library; phage display; recombinant proteins; ribosomal binding site; translation initiation; Bioengineering; Bioteknik;

    Sammanfattning : The bacterium Escherichia coli (E. coli) is in many situations an ideal host for production of recombinant proteins, since it generally provides a rapid and economical means to achieve sufficiently high product quantities. LÄS MER

  4. 18. CRISPRi/a for investigating yeast tolerance to inhibitors in lignocellulosic hydrolysates

    Författare :Ibai Lenitz Etxaburu; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Lignocellulosic hydrolysates; ChIP-exo; Screening; Biosensor; Formic acid; Competitive growth assay; Yeast; Tolerance; CRISPRi a; Acetic acid;

    Sammanfattning : Saccharomyces cerevisiae has immense potential as a cell factory in various biotechnological processes where biomass from agricultural industry residues is used as feedstock. Nonetheless, the inhibitors released during the pretreatment of the biomass makes lignocellulosic hydrolysates a challenging substrate for microorganisms. LÄS MER

  5. 19. Mapping the Golgi retention signal in the G1 membrane glycoprotein of Uukuniemi virus, a member of the Bunyaviridae family

    Författare :Agneta M Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Golgi complex; retention signal; protein transport; virus membrane glycoproteins; virus budding; Uukuniemi virus; Phlebovirus; Bunyaviridae;

    Sammanfattning : Newly synthesized secretory and integral membrane proteins destined for the plasma membrane are transported along the exocytic pathway from the endoplasmic reticulum (ER) via the Golgi complex (GC) to the cell surface. Some of the transported proteins contain information, which target them to their correct intracellular locations. LÄS MER

  7. 20. Amyloid Maturation Patterns in Alzheimer's Disease - Novel chemical imaging of Aβ and Tau pathology

    Författare :Srinivas Koutarapu; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid β; Neurofibrillary Tangles; matrix-assisted laser desorption ionization-mass spectrometry imaging MALDI-MSI ; luminescent conjugated oligothiophenes; Alzheimer’s Disease; Neurodegeneration;

    Sammanfattning : Alzheimer’s disease (AD) accounts for approximately 70% of dementia cases in Sweden. It can be of genetic origin i.e. familial form (fAD), sporadic form (sAD). LÄS MER