Sökning: "intracellular invasion"

Visar resultat 11 - 15 av 50 avhandlingar innehållade orden intracellular invasion.

  1. 11. Signal transduction in human phagocytic cells during phagocytosis, oxidative activation and apoptosis

    Författare :Maria Forsberg; Emmanuelle Caron; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Neutrophils and macrophages are professional phagocytic cells that play a crucial role in host defense against invading microorganisms. They bind to, internalize, and subsequently kill microbes with an arsenal of reactive oxygen metabolites and microbicidal agents. LÄS MER

  3. 12. Dynamic changes in chemotactic and metabolic properties in tumor cells undergoing TGFb1-induced Epithelial-Mesenchymal Transition (EMT)

    Författare :Nikolina Giotopoulou; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epithelial-Mesenchymal Transition (EMT) is a process linked to several hallmarks of cancer including metabolic switching, inflammation, and chemotactic properties. Tumor cells that undergo EMT lose epithelial characteristics like cell-cell adhesion and apical basal polarity and gain expression of mesenchymal proteins including intermediate filaments and various cell surface receptors. LÄS MER

  4. 13. Small molecule inhibitors of type III secretion and their effect on chlamydia development

    Författare :Sandra Muschiol; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chlamydiae are obligate intracellular pathogens that cause a variety of diseases with clinical and public health importance. Like many Gram-negative bacteria, Chlamydiae employ a type III secretion (T3S) system for invasion and establishment of a protected intracellular niche for successful replication and survival within host cells. LÄS MER

  5. 14. Importance of Hyaluronan Metabolism and Signalling in Tumour Progression

    Författare :Berit Bernert; Paraskevi Heldin; Peter Prehm; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; cancer; growth factors;

    Sammanfattning : Hyaluronan, an unbranched glycosaminoglycan of the extracellular matrix, has an amazingly simple structure. Initially thought to fulfil only hydrating and space-filling functions in tissues, evidence generated during the past decades shows that hyaluronan is involved in intriguingly complex signalling events in health and disease. LÄS MER

  7. 15. Regulation of Hyaluronan Synthesis and Signaling via CD44 in Cancer

    Författare :Merima Mehić; Paraskevi Heldin; Carl-Henrik Heldin; Liliana Schaefer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; CD44; TGFβ; PDGF-BB; cancer; signaling; hyaluronan synthase; epithelial-mesenchymal transition; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Hyaluronan is a ubiquitous glycosaminoglycan which is an important constituent of the extracellular matrix (ECM). In addition to organizing the extracellular matrix and regulating tissue homeostasis, hyaluronan, by binding to its main cell surface receptor CD44, is involved in intracellular signaling pathways regulating major cellular processes during development, wound healing, inflammation and cancer. LÄS MER