Sökning: "intestinal epithelial cell"
Visar resultat 1 - 5 av 134 avhandlingar innehållade orden intestinal epithelial cell.
1. New Approaches to Studies of Paracellular Drug Transport in Intestinal Epithelial Cell Monolayers
Sammanfattning : Studies of intestinal drug permeability have traditionally been performed in the colon-derived Caco-2 cell model. However, the permeability of these cell monolayers resembles that of the colon rather than that of the small intestine, which is the major site of drug absorption following oral administration. LÄS MER
2. Human intestinal T lymphocytes : a comparative analysis of phenotype and function in normal and inflamed mucosa
Sammanfattning : The epithelial lining of the gut must allow immediate contact with beneficial components as nutrients and normal microflora. At the same time it runs the constant risk of attack from pathogenic microbes and noxious agents. LÄS MER
3. Involvement of Eicosanoid Signaling in Intestinal Epithelial Cell Survival
Sammanfattning : Eicosanoids are known to be involved in many different aspects of eukaryotic physiology and pathology. Notably, over the past 10 years much attention has been given to cyclooxygenase-2 (COX-2) due to its involvement in colorectal cancer. Less is known about the other major branch of arachidonic acid metabolism, namely the lipoxygenases (LO). LÄS MER
4. O-glycosylation of intestinal and respiratory mucins in health and disease
Sammanfattning : Mucins are large glycoproteins with a diverse O-glycosylation constituting up to 80% of the total mucin mass. The mucus layer covering the epithelial cells of the gastrointestinal and respiratory tract is largely made up of gel-forming mucins. LÄS MER
5. Molecular understanding of KRAS- and BRAF-mutated colorectal cancers
Sammanfattning : Colorectal cancer (CRC) is the third most commonly diagnosed malignancy in both men and women, and one of the leading causes of cancer-related deaths worldwide. One frequently mutated pathway involved in oncogenesis in CRC is the RAS/RAF/MAP kinase pathway. LÄS MER