Sökning: "intermediate filaments"

Visar resultat 21 - 25 av 32 avhandlingar innehållade orden intermediate filaments.

  1. 21. Genetic and pathophysiological study of desmin derangements in cardiac disorders

    Författare :Anna Kostareva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Desmin is a chief intermediate filament of skeletal and cardiac muscle. Its main function is to provide structural and functional integrity to the cell and to transmit tension along the myofibrils, protecting them from mechanical stress during contractionrelaxation process. LÄS MER

  3. 22. Function of contractile and cytoskeletal proteins in smooth muscle: Effects of hypertrophy and age and desmin removal in a transgenic animal

    Författare :Rolf Sjuve; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transgenic mouse; desmin; embryonic myosin; isoforms; myosin heavy chain; age; smooth muscle; hypertrophy; Physiology; Fysiologi;

    Sammanfattning : In man, the urinary bladder responds to an urinary outflow obstruction with a pronounced dilatation and growth of the bladder wall. This clinical situation can be mimicked in rat by creation of a partial urinary outflow obstruction and the papers included in the present thesis use this animal model to address questions regarding the adaptive changes in the smooth muscle of the growing bladder. LÄS MER

  4. 23. Experimental Injury to the Visual System : Molecular Studies of the Retina

    Författare :Ulrika Lönngren; Finn Hallböök; Fredrik Ghosh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retina; injury; ischemia; gene expression; brimonidine; alpha-2-adrenergic agonist; neuroprotection; growth factors; apoptosis; Müller cells; Neuroscience; Neurovetenskap;

    Sammanfattning : Retinal ganglion cells play a crucial role in the relay of visual signals from the eye to the brain. This cell type is affected and eventually lost in the eye disease glaucoma, resulting in progressive and irreversible loss of vision. LÄS MER

  5. 24. Human cytokeratins : their use as targets in cancer management

    Författare :Birgitta Sundström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cytokeratins, biochemically related to intermediate filaments (IF), form an intracellular network of filaments which contributes to the mechanical stabilizing of the cell. 19 individual polypeptides, divided into two groups, constitute the cytokeratin family. LÄS MER

  7. 25. Cell motility : the dynamics of the cortical weave of microfilaments and its relation to microtubules and coated vesicles in fibroblasts and glial cells

    Författare :Anna-Stina Höglund; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Actin and myosin, the major components of the microfilament system are found in most - if not all - eukaryotic cells. In muscle they form the basis of the contractile apparatus which generates the rapid, strong and unidirectional movements that characterizes muscle activity. LÄS MER