Sökning: "interferon gamma production"

Visar resultat 1 - 5 av 41 avhandlingar innehållade orden interferon gamma production.

  1. 1. Multiple Sclerosis: Studies of the Interferon system and search for infectious agents

    Författare :My Bergkvist; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; Neurology; Axon and myelin damage; IgG; Virus; Interferon; Multiple Sclerosis; Genetic linkage;

    Sammanfattning : Multiple sclerosis (MS) is a chronic disease of the central nervous system, characterized by focal inflammatory lesions with demyelination and axonal loss. It is believed that MS is an immune-mediated disorder with both genetic and environmental contributions to the pathogenesis. LÄS MER

  3. 2. B- and T- cell responses in colectomized and healthy individuals after mucosal vaccination

    Författare :Jan Kilhamn; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal immunity; antibodies; interferon gamma production; ileostomy fluid; enteric vaccines; mucosal vaccination;

    Sammanfattning : The overall aims were to study the induction of intestinal and systemic B- and T-cell immune responses in patients colectomized due to ulcerative colitis and in healthy volunteers after mucosal administration of enteric vaccines. An inactivated B-subunit whole-cell (B-WC) cholera vaccine and a live attenuated Salmonella enterica serovar Typhi Ty21a vaccine were used as model immunogens. LÄS MER

  4. 3. Mycobacterial infection: Immune evasion, host susceptibility and immunological markers of diagnostic importance

    Författare :John Arko-Mensah; Carmen Fernandez; Francesco Dieli; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mycobacteria; Mice; Toll-like receptors; interferon gamma; immunological markers; lung; respiratory tract; susceptibility; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : IIn the first study, we investigated the functional implications of prolonged TLR signalling on IFN-γ mediated killing of mycobacteria by murine macrophages in vitro. TLR2, but not TLR4 ligation interfered with IFN-γ mediated killing of mycobacteria in macrophages. LÄS MER

  5. 4. Inflammation and cytokine production in experimental neuroinflammatory disorders

    Författare :Xiang-Yu Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Glutamate excitotoxicity is involved in the pathogenesis of a variety of neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Kainic acid (KA), an analogue of excitotoxic glutamate, can elicit selective neuronal death in the brain of rodents, of which the pathological changes partially mimic the neurodegenerative disorders in humans. LÄS MER

  7. 5. Immunological effects of interferon-beta and glatiramer acetate in multiple sclerosis

    Författare :Yassir Hussien; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multiple sclerosis; Interferon-beta; Glatiramer acetate; Dendritic cells; Mononucealar cells;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in demyelination, axonal loss and neurological deficits. The aetiology is unknown, however, immunopathological events, which are believed to be of an autoimmune nature, are considered to be responsible for the development of the disease. LÄS MER