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Visar resultat 6 - 10 av 28 avhandlingar som matchar ovanstående sökkriterier.

  1. 6. Calcium signaling and network activity : mathematical modeling and molecular mechanisms

    Författare :Erik Smedler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The calcium (Ca2+) ion is a versatile second messenger present in all cells. It is involved in such diverse processes as cell division, differentiation, vesicle transport and muscle contraction. Its widespread applicability is partially explained by its wide temporal and spatial dynamics. LÄS MER

  3. 7. Pathways linking sleep, neuroimmune signaling and pain: an integrative approach

    Författare :Martin Flores Bjurström; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pain; neuroinflammation; inflammation; glia; central sensitization; cerebrospinal fluid; osteoarthritis; chronic postsurgical pain; groin hernia repair; sleep; sleep disturbance; perioperative; neurophysiology;

    Sammanfattning : Background and objectives: Neuroinflammation is implicated in the development and maintenance of persistent pain states, but there is limited data linking cerebrospinal fluid (CSF) inflammatory mediators with neurophysiological pain processes in humans. Study I aimed to investigate whether there are coherent changes in CSF inflammation associated with central sensitization (CS), and to evaluate potential differences in CSF levels of inflammatory mediators between osteoarthritis (OA) patients with disabling pain and pain-free controls. LÄS MER

  4. 8. Innate immunity atherosclerosis : signaling pattern recognition receptors and an antimicrobial peptide

    Författare :Kristina Edfeldt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherosclerosis; innate immunity; inflammation; Toll-like receptor; nucleotide oligomerization domain protein; antimicrobial peptide;

    Sammanfattning : Atherosclerosis, a disease characterized by fibroinflammatory lipid lesions in the arterial wall, is the leading cause of mortality in the Western world. For decades research has been aimed at dissecting the pathogenesis of this multifactorial disease. LÄS MER

  5. 9. Ligand-receptor interactions and signaling cross-talk in the TGF-b superfamily

    Författare :Andries Blokzijl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The transforming growth factor-beta (TGF-beta) superfamily of secreted polypeptide growth factors forms part of an evolutionary conserved signaling pathway, present in diverse organisms from flies to humans, used in intercellular communication. The TGF-beta family comprises more than 40 members in vertebrates, Caenorhabditis elegans and Drosophila melanogaster. LÄS MER

  7. 10. NFAT signaling in chronic and acute inflammation - A novel target for the treatment of diabetic vascular complications and acute pancreatitis?

    Författare :Anna Zetterqvist; Diabetiska komplikationer; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NFAT; vascular; diabetes; inflammation; atherosclerosis; diabetic retinopathy; acute pancreatitis; osteopontin; VCAM-1; A-285222;

    Sammanfattning : Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. LÄS MER