Sökning: "intercellular signaling"

Visar resultat 6 - 10 av 22 avhandlingar innehållade orden intercellular signaling.

  1. 6. Calcium signaling and network activity : mathematical modeling and molecular mechanisms

    Författare :Erik Smedler; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The calcium (Ca2+) ion is a versatile second messenger present in all cells. It is involved in such diverse processes as cell division, differentiation, vesicle transport and muscle contraction. Its widespread applicability is partially explained by its wide temporal and spatial dynamics. LÄS MER

  2. 7. Innate immunity atherosclerosis : Signaling pattern recognition receptors and an antimicrobial peptide

    Författare :Kristina Edfeldt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Atherosclerosis; innate immunity; inflammation; Toll-like receptor; nucleotide oligomerization domain protein; antimicrobial peptide;

    Sammanfattning : Atherosclerosis, a disease characterized by fibroinflammatory lipid lesions in the arterial wall, is the leading cause of mortality in the Western world. For decades research has been aimed at dissecting the pathogenesis of this multifactorial disease. LÄS MER

  3. 8. Ligand-receptor interactions and signaling cross-talk in the TGF-b superfamily

    Författare :Andries Blokzijl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The transforming growth factor-beta (TGF-beta) superfamily of secreted polypeptide growth factors forms part of an evolutionary conserved signaling pathway, present in diverse organisms from flies to humans, used in intercellular communication. The TGF-beta family comprises more than 40 members in vertebrates, Caenorhabditis elegans and Drosophila melanogaster. LÄS MER

  4. 9. NFAT signaling in chronic and acute inflammation - A novel target for the treatment of diabetic vascular complications and acute pancreatitis?

    Författare :Anna Zetterqvist; Diabetiska komplikationer; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NFAT; vascular; diabetes; inflammation; atherosclerosis; diabetic retinopathy; acute pancreatitis; osteopontin; VCAM-1; A-285222;

    Sammanfattning : Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. LÄS MER

  5. 10. Intratumoral heterogeneity in glioblastoma: subtype transition and cell-to-cell communication

    Författare :Min Guo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; glioblastoma; intratumoral heterogeneity; subtype transition; intercellular communication; U-343; SOX2; SFRP2; PROX1; THRAP3; TGFBI; NOTCH1; and ADAMTS1;

    Sammanfattning : Glioblastoma is a most aggressive brain tumor with a median overall survival of less than two years. The current treatment is surgery, chemotherapy, and radiotherapy. However, glioblastoma is difficult to treat and recurs some time after treatment. LÄS MER