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Visar resultat 11 - 15 av 28 avhandlingar som matchar ovanstående sökkriterier.

1. 11. Intratumoral heterogeneity in glioblastoma: subtype transition and cell-to-cell communication

   Författare :Min Guo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :glioblastoma; intratumoral heterogeneity; subtype transition; intercellular communication; U-343; SOX2; SFRP2; PROX1; THRAP3; TGFBI; NOTCH1; and ADAMTS1;

   Sammanfattning : Glioblastoma is a most aggressive brain tumor with a median overall survival of less than two years. The current treatment is surgery, chemotherapy, and radiotherapy. However, glioblastoma is difficult to treat and recurs some time after treatment. LÄS MER

3. 12. Analytical Approaches to Study Vesicular and Exosomal Release

   Författare :Kim Long Le Vo; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Vesicles, as a special type of entity nanometers in size, are crucial for survival of multicellular organisms. Intracellular vesicles mainly contain specific signaling molecules, transmitters, and modulators whereas extracellular vesicles (EVs) are bioactive organelles carrying a wide range of proteins, genetic materials, and other molecules. LÄS MER

4. 13. Unraveling the role of NOTCH3 dysfunction in disease and for therapy development : a focus on CADASIL

   Författare :Daniel V Oliveira; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The Notch signaling pathway, including the Notch3 receptor, is involved in many pivotal contexts of cell signaling and cell fate determination processes during development and in adulthood. Different mutations in the NOTCH3 receptor, which is highly expressed in vascular smooth muscle cells (VSMC), are associated with various diseases, including developmental disorders, several forms of cancer, and vascular dementia. LÄS MER

5. 14. Visualizing Interacting Biomolecules In Situ

   Författare :Irene Weibrecht; Ola Söderberg; Ulf Landegren; Banafshe Larijani; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation; in situ PLA; padlock probe; rolling circle amplification; flow cytometry; in situ; single cell; single molecule; protein interaction; protein-DNA interaction; posttranslational modification; Molecular medicine; Molekylär medicin; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Intra- and intercellular information is communicated by posttranslational modifications (PTMs) and protein-protein interactions, transducing information over cell membranes and to the nucleus. A cells capability to respond to stimuli by several highly complex and dynamic signaling networks provides the basis for rapid responses and is fundamental for the cellular collaborations required in a multicellular organism. LÄS MER

7. 15. New insights into the regulation of stomatal movements by red light, carbon dioxide and circadian rhythms

   Författare :Anastasia Matrosova; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Stomata are small adjustable pores formed by pairs of guard cells that enable gas exchange between leaves and the atmosphere, thus directly affecting water loss and CO₂ uptake in plants. The current work focuses on the regulation of stomatal movements by red light, carbon dioxide and the circadian system and attempts to uncover molecular mechanisms that control guard cell function. LÄS MER