Sökning: "intercellular junctions"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden intercellular junctions.

  1. 1. Applications of organ culture of the mouse inner ear

    Författare :Diana Berggren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; organ culture; embryonic inner ear; intercellular junctions; aminoglycosides; statoacoustic ganglion; intermediate filaments; collagen; endolymph;

    Sammanfattning : The embryonic mouse inner ear was used as a model with which to study ototoxicity and tissue interactions. The inner ear anlage can be explanted and cultured in vitro from about the 12th gestational day (gd), and will differentiate parallel with the inner ear developing in vivo until a time corresponding to birth (21st gd). LÄS MER

  3. 2. Connexin43 in astroglial gap junctions. Regulation by age, neurotransmitters, GH and IGF-I

    Författare :N David Åberg; Göteborgs universitet; []
    Nyckelord :Connexin43; rat; development; hypophysectomy; primary culture; ; mRNA; gap junction; somatotropin; IGF-I; serotonin; glutamate; ; brain region heterogeneity; calcium wave; astrocyte; astroglial cell; ; gap junctional coupling.;

    Sammanfattning : Connexins form gap junctions that are aqueous pores allowing low-molecular (.... LÄS MER

  4. 3. Mechanistical studies on gap junctions and their role in tumour promotion : structure-activity relationships of polychlorinated biphelyls

    Författare :Yvonne Bager; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :gap junctional intercellular communication; phosphorylation; tumour promotion; alteredhepatic foci; rat liver; potency; PCBs; TCDD.Doctoral Thesis Yvonne Bager;

    Sammanfattning : Chemically induced carcinogenesis is a multi-stage process that can be divided into at least three major stages, initiation, promotion and progression. The promotion stage involves clonal expansion of genetically altered cells (i.e. initiated cells). LÄS MER

  5. 4. Protein kinase C-dependent regulation of the epithelial barrier

    Författare :Anita Sjö; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The intestinal epithelium is essential for the absorption of nutrients and for the defence against harmful substances in the gut. The permeability and barrier functions of epithelia are mainly controlled by the intercellular tight junctions. LÄS MER

  7. 5. Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models

    Författare :Thomas Asklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glioma; gap junction; Cx43; bystander effect; HSV-tk; HDAC inhibitor; tyrosine kinase inhibitor;

    Sammanfattning : The group of patients suffering from the malignant brain tumour glioblastoma multiforme (GBM) have a median survival of only about one year. Thus, new treatment strategies are urgently needed. Gap junctions are intercellular channels, permitting intercellular transfer of water soluble substances. LÄS MER