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Visar resultat 1 - 5 av 24 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Energy and intensity modulated radiation therapy with electrons

    Författare :Lennart Olofsson; Mikael Karlsson; Magnus Karlsson; Björn Zackrisson; Erik Traneus; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; Radiation therapy; Conformal therapy; IMRT; Electrons; Electron treatment head; Electron MLC; Bremsstrahlung reduction; Integral dose; Penumbra; Output factor; Strålningsvetenskap; Radiation biology; Strålningsbiologi; radiofysik; radiation physics;

    Sammanfattning : In recent years intensity modulated radiation therapy with photons (xIMRT) has gained attention due to its ability to reduce the dose in the tissues close to the tumour volume. However, this technique also results in a large low dose volume. LÄS MER

  2. 2. Multicriteria optimization for managing tradeoffs in radiation therapy treatment planning

    Författare :Rasmus Bokrantz; Anders Forsgren; Karl-Heinz Küfer; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimization; multicriteria optimization; robust optimization; Pareto optimality; Pareto surface approximation; Pareto surface navigation; intensity-modulated radiation therapy; volumetric-modulated arc therapy; intensity-modulated proton therapy; Optimering; flermålsoptimering; robust optimering; Paretooptimalitet; Paretofrontsapproximation; Paretofrontsnavigering; intensitetsmodulerad strålterapi; rotationsterapi; intensitetsmodulerad protonterapi;

    Sammanfattning : Treatment planning for radiation therapy inherently involves tradeoffs, such as between tumor control and normal tissue sparing, between time-efficiency and dose quality, and between nominal plan quality and robustness. The purpose of this thesis is to develop methods that can facilitate decision making related to such tradeoffs. LÄS MER

  3. 3. Robust optimization of radiation therapy accounting for geometric uncertainty

    Författare :Albin Fredriksson; Anders Forsgren; Timothy C. Y. Chan; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimization; intensity-modulated proton therapy; uncertainty; robust planning; setup error; range error; intensity-modulated radiation therapy; multicriteria optimization;

    Sammanfattning : Geometric errors may compromise the quality of radiation therapy treatments. Optimization methods that account for errors can reduce their effects.The first paper of this thesis introduces minimax optimization to account for systematic range and setup errors in intensity-modulated proton therapy. LÄS MER

  4. 4. Automated radiation therapy treatment planning by increased accuracy of optimization tools

    Författare :Lovisa Engberg; Anders Forsgren; Marina A. Epelman; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Optimization; intensity-modulated radiation therapy; radiation therapy treatment planning; automated radiation therapy treatment planning; interior-point methods; Optimering; intensitetsmodulerad strålbehandling; dosplanering; automatiserad dosplanering; inrepunktsmetoder; Mathematics; Matematik;

    Sammanfattning : Every radiation therapy treatment is preceded by a treatment planning phase. In this phase, a treatment plan that specifies exactly how to irradiate the patient is designed by the treatment planner. LÄS MER

  5. 5. Accurate description of heterogeneous tumors for biologically optimized radiation therapy

    Författare :Johan Nilsson; Bengt Lind; Anders Brahme; Margareta Edgren; Søren Bentzen; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heterogeneous tumors; radiation therapy; biological optimization; tumor hypoxia; effective radiation sensitivity; effective radiation resistance; Radiation biology; Strålningsbiologi;

    Sammanfattning : In this thesis, a model of tissue oxygenation is presented, that takes into account the heterogeneous nature of tumor vasculature. Even though the model is rather simple, the resulting oxygen distributions agree very well with clinically observed oxygen distributions for most tumors and healthy normal tissues. LÄS MER