Sökning: "integrin"

Visar resultat 21 - 25 av 190 avhandlingar innehållade ordet integrin.

  1. 21. Basement membrane components and their receptors in organogenesis

    Författare :Katriina Salmivirta; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Basement membrane; laminin; collagen type IV; nidogen; integrin; morphogenesis; organogenesis; tooth; salivary gland; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; fysiologi; Physiology;

    Sammanfattning : During embryogenesis organs are formed from epithelial and mesenchymal tissues. Organogenesis is dependent on interactions between epithelium and mesenchyme. Specialized extracellular matrices, basement membranes, located between the two tissue types play a crucial role in mediating the interactions. LÄS MER

  3. 22. Novel roles of ErbB3 receptor tyrosine kinase in vesicular trafficking

    Författare :Ana Rosa Saez-Ibañez; Ingvar Ferby; Carl-Henrik Heldin; Johanna Ivaska; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ErbB3; Integrin; GGA3; Rabaptin5; PKD; Ack1; endocytic recycling; exosome; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi;

    Sammanfattning : ErbB3 is a catalytically impaired receptor tyrosine kinase (RTK) from the EGFR family. Upon ligand binding, ErbB3 forms heterodimers with other members of the family and triggers phosphorylation cascades that promote crucial cellular functions as proliferation, differentiation and survival. LÄS MER

  4. 23. Fibromodulin and chondroadherin in connective tissue homeostasis

    Författare :Viveka Tillgren; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Collagen; integrin; cell surface proteoglycan; extracellular matrix; and small leucine-rich repeat proteoglycan.;

    Sammanfattning : Connective tissue contains a prominent extracellular matrix (ECM), which provides for physiological and mechanical properties. Intra- and inter-molecular interactions between proteins in this ECM provide for the formation of molecular networks. These interactions determine the shape of the tissue as well as cell behavior. LÄS MER

  5. 24. Expression and regulation of CCL25 and its role in T cell localization to and function within the small intestine

    Författare :Anna Ericsson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosa; epithelium; intestine; transplantation; serology; Immunologi; Immunology; integrin; serologi; Chemokine;

    Sammanfattning : Earlier studies have demonstrated an important role for the chemokine CCL25, and its receptor CCR9, in the generation of the small intestinal lymphocyte compartment. The work in this thesis was aimed at determining how CCL25 is regulated within the small intestinal mucosa, and what potential role it plays in T cell localization to and function within this site. LÄS MER

  7. 25. Transmigration of Toxoplasma gondii across biological barriers

    Författare :Emily C. Ross; Antonio Barragan; Ildiko Rita Dunay; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Apicomplexa; blood-brain barrier; leukocyte; immune cell; transendothelial migration; cell adhesion molecule; host-pathogen; FAK; integrin; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Toxoplasma gondii is an obligate intracellular parasite that can likely infect all warm-blooded vertebrates, with estimates of up to 30% of the global human population being infected. Although infection with T. gondii is usually asymptomatic or mild, in immunocompromised individuals infection can lead to lethal toxoplasmic encephalitis. LÄS MER