Sökning: "integrin regulation"

Visar resultat 1 - 5 av 66 avhandlingar innehållade orden integrin regulation.

  1. 1. Structural and Functional Aspects of β1 Integrin Signalling

    Författare :Stina Nilsson; Staffan Johansson; Teet Velling; Maria Fällman; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; Integrin; Integrin subunit β1; Integrin activation; Threonine; Phosphorylation; Integrin signalling; FAK; PI3K; MAPK; Cell- och molekylärbiologi;

    Sammanfattning : Integrins are transmembrane glycoproteins primarily mediating interactions of cells with the extracellular matrix. Each receptor is a complex of one α- and one β-subunit with affinity for a diverse set of ligands. LÄS MER

  3. 2. Integrin Signaling in Cell Adhesion and Mechanotransduction : Regulation of PI3K, AKT, and ROS

    Författare :Kathrin Stephanie Zeller; Staffan Johansson; Kristofer Rubin; John Couchman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; integrin; ROS; PI3K; AKT; mechanosignaling; actin polymerization; spreading;

    Sammanfattning : Integrins are a family of conserved cell surface receptors found throughout the animal kingdom. They comprise 24 dimers in mammals, and regulate a number of processes including cell survival, differentiation, and migration. LÄS MER

  4. 3. Syndecan - Regulation and Function of its Glycosaminoglycan Chains

    Författare :Anna S. Eriksson; Dorothe Spillmann; Catherine Merry; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heparan sulfate; chondroitin sulfate; integrin; cell motility; fibroblast growth factor signaling; pharyngeal cartilage; biosynthesis regulation; Medical Science; Medicinsk vetenskap;

    Sammanfattning : The cell surface is an active area where extracellular molecules meet their receptors and affect the cellular fate by inducing for example cell proliferation and adhesion. Syndecans and integrins are two transmembrane molecules that have been suggested to fine-tune these activities, possibly in cooperation. Syndecans are proteoglycans, i.e. LÄS MER

  5. 4. Regulation of leukocyte integrin adhesiveness

    Författare :Håkan Hedman; Erik Lundgren; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lymphocytes; Cell Adhesion; Integrins; LFA-1; VLA-4; ICAM-1; VCAM-1; Microvesicles; Protein Kinases; Protein Phosphatases;

    Sammanfattning : .... LÄS MER

  7. 5. Functional analysis of the alpha10beta1 integrin

    Författare :Therese Bengtsson; Malmö Experimentell patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cytogenetics; Genetik; cytogenetik; limb; gene targeting; chondrocyte; integrin; cartilage;

    Sammanfattning : The aim of this thesis was to study the function of the integrin a10b1. Integrins mediate signals between cells and their environment and regulate several cellular processes such as cell migration, proliferation and differentiation. LÄS MER