Sökning: "integrase"

Visar resultat 6 - 10 av 24 avhandlingar innehållade ordet integrase.

1. 6. Palladium-Catalysed Carbon–Carbon Coupling Reactions : Focusing on Microwave Heating, Low Catalyst Concentrations, Aqueous Conditions, Regioselectivity and Medicinal Chemistry Applications

   Författare :Riina K Arvela; Mats Larhed; Anders Hallberg; Michael G Organ; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Suzuki coupling; Heck reaction; palladium; microwave heating; water; vinyl ethregioselective; HIV-1 integrase inhibitor; Pharmaceutical chemistry; Farmaceutisk kemi; farmaceutisk biokemi; Pharmaceutical Biochemistry;

   Sammanfattning : It is widely accepted that palladium is one of the most useful catalysts in organic chemistry, and many palladium(0)-catalysed carbon–carbon bond-forming reactions have been developed over the years. In addition, the ever-growing need for more environmentally benign processes in the chemical industry has driven scientists to look for greener options while developing new methodologies for organic synthesis. LÄS MER

3. 7. The HIV-1 epidemic in Ethiopia – transmission patterns, antiretroviral drug resistance and treatment outcomes

   Författare :Dawit Assefa; Malmö Klinisk virologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV drug resistance HIVDR ; Phylodynamics; Phylogenetic; Molecular epidemology; transmitted HIVDR; acquired HIVDR; pre-treatment HIVDR; Integrase strand transfer inhibitors INSTI ; Ethiopia; antiretroviral therapy;

   Sammanfattning : A comprehensive understanding of local HIV epidemiology is essential for monitoring transmission, designing, implementing, and evaluating HIV intervention strategies. In paper I, we used a total of 1276 HIV-1 subtype C pol sequences and employed state-of-art phylogenetic and phylodynamic tools to describe the molecular epidemiology of HIV in Ethiopia. LÄS MER

4. 8. Site-Specific Recombination : Integrases, Accessory Factors and DNA Targets of P2-like Coliphages

   Författare :Lina Sylwan; Elisabeth Haggård-Ljungquist; Margaret C. M. Smith; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

   Sammanfattning : The temperate coliphage P2 and its family members integrate their genomes into the host Escherichia coli chromosome by a site-specific recombination mechanism to form lysogeny. Integration takes place between the complex phage attP site and the simple bacterial attB site and is catalyzed by the phage encoded integrase (Int). LÄS MER

5. 9. Characterization of a site-specific gene-transfer mechanism in bacteria

   Författare :Karin Hansson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Pharmaceutical Microbiology; farmaceutisk mikrobiologi;

   Sammanfattning : Integrons capture and rearrange single genes borne on mobile units called cassettes using site-specific recombination. The integrons increase the variation of antibiotic resistance among bacterial plasmids and may also reorganize clustered genes in bacterial genomes. LÄS MER

7. 10. Mechanisms and DNA Specificity in Site-specific Recombination of Integron Cassettes

   Författare :Carolina Johansson; Lars Sundström; Dan Andersson; Didier Mazel; Uppsala universitet; []
   Nyckelord :Microbiology; lateral gene transfer; site-specific recombination; tyrosine recombinase; integron; single-stranded; DNA hairpin; Mikrobiologi; farmaceutisk mikrobiologi; Pharmaceutical Microbiology;

   Sammanfattning : Bacterial resistance to antibiotics has become a serious problem. This is due to the remarkable ability of bacteria to respond and rapidly adapt to environmental changes. Integrons are elements with the capacity for gene capture by an integron-encoded site-specific recombinase called IntI. LÄS MER