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Visar resultat 1 - 5 av 64 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Targeting insulin-like growth factor-1 receptor in cancer

   Författare :Ada Girnita; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF1; IGF-1R; MDM2; p53; PPP; Tamoxifen; tyrosine kinase inhibitors; ubiquitin;

   Sammanfattning : Cancer is a multi-step process where the accumulation of several genetic and epigenetic alterations drives the transformation of a normal cell to a malignant cell, skipping the normal control of defense, repair and apoptosis. During the selection process towards a malignant phenotype, the transforming cells make use of normal (physiological) extracellular signaling pathways to create growth advantage over normal cells. LÄS MER

3. 2. Insulin-like growth factor 1 receptor, novel functions and future possibilities

   Författare :Ahmed Waraky; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces transphosphorylation and activation of the receptor, leading to subsequent activation of the phosphatidyl inositol-3 kinase (PI3K), the mitogen-activated protein kinase (MAPK) and the 14-3-3 pathways. LÄS MER

4. 3. Regulation of insulin-like growth factor-1 receptor expression and signaling

   Författare :Radu Vasilcanu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF-1R; â-arrestins; MDM2; ubiquitination; internalization;

   Sammanfattning : Insulin-like growth factor-1 receptor (IGF-1R), a member of the insulin receptor tyrosine kinase family is a broadly expressed transmembrane receptor that plays a key role in malignant cell growth. IGF-1R transmits information provided by extracellular stimuli into intracellular signaling pathways resulting in the subsequent regulation of various effector systems. LÄS MER

5. 4. On testosterone during alcohol withdrawal in men : effects on mood and insulin-like growth factor 1

   Författare :Jaan Ruusa; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ethyl alcohol; withdrawal; testosterone; insulin-like growth factor 1; mood;

   Sammanfattning : The decrease of testosterone levels after alcohol ingestion is seen in both non-alcoholic and alcohol dependent patients. Mood effects during hangover and alcohol detoxification are common symptoms. In ageing men a connection has been observed between lowered testosterone levels and depressive symptoms as well as cognitive impairment. LÄS MER

7. 5. Signaling to the immature brain - Choroid plexus, insulin-like growth factor 1 and extracellular vesicles

   Författare :Niklas Ortenlöf; Lund Pediatrik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IGF-1; Choroid plexus; Immature brain; Extracellular vesicle; CSF; Preterm infants;

   Sammanfattning : Extremely preterm infants (i.e., born below 28 gestational weeks), are at high risk of developing brain morbidities including intraventricular hemorrhage (IVH) and neurodevelopmental impairment. Despite over 50 years of research, there is currently no effective therapy available for preventing IVH. LÄS MER