Sökning: "insulin-like growth factor binding proteins"

Visar resultat 21 - 25 av 39 avhandlingar innehållade orden insulin-like growth factor binding proteins.

1. 21. Diabetic osteopathy : a study in the rat

   Författare :Tashfeen Ahmad; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Diabetes mellitus type 2; Goto-Kakizaki rat; bone mineral density; insulin-like growth factor-I; insulin-like growth factor binding protein 1; insulin-like growth factor binding protein 4; peripheral neuropathy; substance P; calcitonin gene-related peptide; neuropeptide Y; Diabetes mellitus type 2;

   Sammanfattning : The present study on non-obese Goto-Kakizaki (GK) rats with type-2 diabetes and neuropathy was an attempt to describe and define pertinent features of diabetic osteopathy. Altogether, the study included 33 GK rats aged 12 and 20 months, and 36 age-matched Wistar rats as controls. LÄS MER

3. 22. Action and interaction of growth factors and regulatory molecules in vascular cells : With special reference to the IGF-I-system

   Författare :Gunilla Dahlfors; Anna Hultgårdh-Nilsson; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Vascular function is greatly influenced by growth factors and regulatory molecules that can interact with each other in a complex pattern in the vascular wall. In this thesis we studied how different substances of special interest in the pathogenesis of vascular disease interact and regulate each other's expressions in endothelial cells and vascular smooth muscle cells (VSMCs). LÄS MER

4. 23. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors

   Författare :Steven Gray; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Liver Tumor; Histone Aceltylation; Gene expression; trichostatin A; Insulin-like growth factor axis; Comparative genomic hybridization; Spectral karyotyping;

   Sammanfattning : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. LÄS MER

5. 24. Exposures in utero and chronic disease : an alternative methodological approach

   Författare :Anna Hübinette; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cardiovascular disease; acute myocardial infarction; angina pectoris; breast neoplasms; birth weight; birth anthropometrics; twin study; epidemiology; etiology; risk factors; insulin-like growth factors; preeclampsia; longitudinal study.;

   Sammanfattning : The aims of this thesis were to evaluate maternal and birth characteristics as risk factors for breast cancer and cardiovascular disease later in life, and to assess maternal serum concentrations of insulin-like growth factors in pregnancies complicated by preeclampsia. Birth characteristics and risks of breast cancer were studied in a case-control study nested within the population-based Swedish Twin Register (Paper 1). LÄS MER

7. 25. Expression and function of IGF-I and insulin receptors in human micro- and macrovascular cells

   Författare :Simona I. Chisalita; Hans J. Arnqvist; Torbjorn Lindström; Per-Anders Jansson; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Insulin-like growth factor and insulin are phylogenetically closely related polypeptides and have large structural and biological similarities. Low circulating insulin-like growth factor-I (IGF-I), diabetes as well as insulin resistance have been implicated in the pathogenesis of cardiovascular disease, but the mechanisms involved are still not clear. LÄS MER