Sökning: "insulin-like growth factor binding protein 4"

Visar resultat 1 - 5 av 35 avhandlingar innehållade orden insulin-like growth factor binding protein 4.

1. 1. Proteolysis of insulin-like growth factor-binding protein-1, -2 and -4 : function of fragments

   Författare :Katrin Brandt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Insulin-like growth factor;

   Sammanfattning : The insulin-like growth factors (IGF-I and IGF-II) stimulate cell growth, survival and differentiation, and have insulin-like activity. A family of six IGF-binding proteins (IGFBP-1 through -6) bind to IGFs with high affinity and modulate their activity in the circulation and locally at cell-surface receptors. LÄS MER

3. 2. Insulin-like growth factor binding protein-3 : structure and function

   Författare :Maria Ahlsén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Insulin-like growth factor (IGF) -I and -II share structural homology with insulin. Their receptors and intracellular signaling are similar. Consequently, the biological actions of IGFs and insulin are overlapping. Insulin is secreted on demand depending on e. LÄS MER

4. 3. Novel insulin-like growth factor-binding protein proteases : detection and characterization

   Författare :Jing Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGFs; IGFBP-1. IGFBP-3; azurocidin HBP CAP37; IGFBP protease; gender;

   Sammanfattning : Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins (IGFBP-1 to -6) control the availability of IGFs (IGF-I and IGF-II) to their receptors. LÄS MER

5. 4. Human insulin-like growth factor binding protein-4 and -6 : gene structure and transcription regulation

   Författare :Henric Zazzi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :IGF binding proteins IGFBP ; DNA sequencing; chromosomal localization; gene expression; Sp I; NF-kappa-B; methylation;

   Sammanfattning : Insulin-like growth factors (IGF-I and IGF-II) are among the more abundant growth factors isolated from bone tissue and are synthesized by various bone cells including osteoblasts. The activity of IGFs is controlled by a family of binding proteins (IGFBPs) divided into subfamilies depending on their individual affinity for IGFs. LÄS MER

7. 5. Diabetes in adolescent girls : Endocrine influences on metabolic control with special regard to the GHI/IGF-I Axis

   Författare :Maria Halldin Stenlid; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; Insulin dependent diabetes; adolescent; growth hormone; insulin-like growth factor-I; insulin-like growth factor binding protein1; insulin sensitivity; pirenzepine; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; pediatrik; Pediatrics;

   Sammanfattning : Metabolic control frequently deteriorates during puberty in girls with IDDM, and is often accompanied by excessive weight gain. This impairment has been ascribed the peripubertal psychosocial as well as somatic changes. Puberty is characterised by a unique endocrine milieu. LÄS MER