Sökning: "insulin-like growth factor I"

Visar resultat 16 - 20 av 164 avhandlingar innehållade orden insulin-like growth factor I.

  1. 16. Insulin-like growth factor-II : cellular effects through different receptors

    Författare :Qimin Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Insulin-like growth factor-II (IGF-II) and IGF-I are single-chain polypeptides structurally homologous to proinsulin and share similarities with insulin in functional characteristics. Cellular actions of IGF-II are generally thought to be mediated through the IGF-I or insulin receptors, but not the IGF-II receptor, which is a single chain protein, identical to the cation independent mannose 6-phosphate (M6P) receptor and responsible for lysosomal enzyme targeting and degradation of IGF-II. LÄS MER

  3. 17. The insulin-like growth factor system : effects of circulating proteases

    Författare :Sara Gustafsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The insulin-like growth factor-I and -II (IGF-I/-II) are peptide hormones important for growth and metabolism. They stimulate cell proliferation and differentiation and inhibit apoptosis. In addition, they have insulin-like effects on glucose and amino acid metabolism. LÄS MER

  4. 18. Insulin-like growth factor binding protein-3 : structure and function

    Författare :Maria Ahlsén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Insulin-like growth factor (IGF) -I and -II share structural homology with insulin. Their receptors and intracellular signaling are similar. Consequently, the biological actions of IGFs and insulin are overlapping. Insulin is secreted on demand depending on e. LÄS MER

  5. 19. Novel insulin-like growth factor-binding protein proteases : detection and characterization

    Författare :Jing Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :IGFs; IGFBP-1. IGFBP-3; azurocidin HBP CAP37; IGFBP protease; gender;

    Sammanfattning : Members of the insulin-like growth factor (IGF) system are known to have an impact on cell differentiation, proliferation and survival, and to be important regulators for nutrient metabolism. The IGF-binding proteins (IGFBP-1 to -6) control the availability of IGFs (IGF-I and IGF-II) to their receptors. LÄS MER

  7. 20. Insulin-like growth factor 1 receptor, novel functions and future possibilities

    Författare :Ahmed Waraky; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces transphosphorylation and activation of the receptor, leading to subsequent activation of the phosphatidyl inositol-3 kinase (PI3K), the mitogen-activated protein kinase (MAPK) and the 14-3-3 pathways. LÄS MER