Sökning: "insulin-like growth factor I IGF-I"

Visar resultat 6 - 10 av 95 avhandlingar innehållade orden insulin-like growth factor I IGF-I.

  1. 6. Diabetes in adolescent girls : Endocrine influences on metabolic control with special regard to the GHI/IGF-I Axis

    Författare :Maria Halldin Stenlid; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obstetrics and gynaecology; Insulin dependent diabetes; adolescent; growth hormone; insulin-like growth factor-I; insulin-like growth factor binding protein1; insulin sensitivity; pirenzepine; Obstetrik och kvinnosjukdomar; Obstetrics and women s diseases; Obstetrik och kvinnosjukdomar; pediatrik; Pediatrics;

    Sammanfattning : Metabolic control frequently deteriorates during puberty in girls with IDDM, and is often accompanied by excessive weight gain. This impairment has been ascribed the peripubertal psychosocial as well as somatic changes. Puberty is characterised by a unique endocrine milieu. LÄS MER

  3. 7. Insulin-like growth factor-I from a perspective of bone regeneration

    Författare :Per Prisell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :insulin-like growth factor-I; fracture healing; endochondral bone formation; slow release; indomethacin; corticosteroids; hyaluronan; von Kossa;

    Sammanfattning : The insulin-like growth factor I (IGF-I) is produced by osteoblasts and many other cell types. IGF-I is abundant in bone matrix and mediates some of the effects of growth hormone (GH). The present investigations have focused on IGF-I actions during bone regeneration. LÄS MER

  4. 8. Life, death ant the role of IGF-I in human multiple myeloma

    Författare :Patrik Georgii-Hemming; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Multiple Myeloma; IGF-I; apoptosis; Fas; glucocorticoids; somatostatin; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Multiple myeloma (MM) is a clonal expansion of malignant cells with a plasmablast- plasma cell morphology in the bone marrow. It is a fatal disease with a median survival of 2-3 years after start of conventional therapy. LÄS MER

  5. 9. Experimental studies on the effects of insulin-like growth factor I and glucocorticoids on bone metabolism

    Författare :Kenneth B. Jonsson; Uppsala universitet; []
    Nyckelord :Medical sciences; Bone; bone resorption; glucocorticoids; insulin-like growth factor I; osteoblasts; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Osteoporosis is a major cause of disability among patients that are dependent on glucocorticoids in the treatment of inflammatory disease. The pathogenesis behind this side effect is complex, involving dysregulation of hormonal systems and direct effects on bone cells. LÄS MER

  7. 10. Expression and function of IGF-I and insulin receptors in human micro- and macrovascular cells

    Författare :Simona I. Chisalita; Hans J. Arnqvist; Torbjorn Lindström; Per-Anders Jansson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Insulin-like growth factor and insulin are phylogenetically closely related polypeptides and have large structural and biological similarities. Low circulating insulin-like growth factor-I (IGF-I), diabetes as well as insulin resistance have been implicated in the pathogenesis of cardiovascular disease, but the mechanisms involved are still not clear. LÄS MER