Sökning: "insulin secretion"
Visar resultat 11 - 15 av 402 avhandlingar innehållade orden insulin secretion.
11. Pathophysiology and treatment of defective insulin secretion in diabetes
Sammanfattning : Defective insulin secretion is a central feature in diabetes mellitus and results from reduced pancreatic beta-cell mass as well as aberrant beta-cell function. The pathophysiology of diabetes is incompletely known, but a strong hereditary component is suggested. LÄS MER
12. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects
Sammanfattning : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. LÄS MER
13. Ion channel control of phasic insulin secretion
Sammanfattning : Glucose-stimulated insulin secretion exhibits a biphasic pattern. The mechanism underling biphasic insulin secretion is not fully understood, but consensus exists that an elevation in [Ca2+]i is required for both first- and second-phase insulin secretion. LÄS MER
14. Mechanisms of defective insulin secretion in type 2 diabetes
Sammanfattning : Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. LÄS MER
15. Oscillatory Signaling and Insulin Secretion from Single ß-cells
Sammanfattning : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. LÄS MER