Sökning: "insulin resistance"

Visar resultat 11 - 15 av 474 avhandlingar innehållade orden insulin resistance.

  1. 11. Interplay between hormones, nutrients and adipose depots in the regulation of insulin sensitivity : an experimental study in rat and human adipocytes

    Författare :Magdalena Lundgren; Jan Eriksson; Jonas Burén; Eva Degerman; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; adipose tissue; cAMP; glucocorticoids; glucose; insulin; insulin resistance; lipolysis; subcutaneous fat; type 2 diabetes; visceral fat; Medicine; Medicin;

    Sammanfattning : Obesity and specifically central obesity is related to insulin resistance, type 2 diabetes and other components of the so-called metabolic syndrome. The aim of this study was to elucidate the interplay between hormones, nutrients and adipose depots in normal and insulin-resistant fat cell metabolism. LÄS MER

  3. 12. Novel insights into the regulation of insulin secretion by GLP-1, GIP and glucagon

    Författare :Linda Ahlkvist; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vagus nerve; GPR119; Insulin resistance; Glucagon; GIP; GLP-1; Insulin;

    Sammanfattning : There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. LÄS MER

  4. 13. Muscle Morphology and the Insulin Resistance Syndrome : A Population-Based Study of 70 Year-Old-Men in Uppsala

    Författare :Anu Hedman; Stevo Julius; Uppsala universitet; []
    Nyckelord :Medical sciences; Muscle morphology; fiber distribution; capillary density; insulin resistance syndrome; physical activity; hypertension; insulin-mediated blood flow; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Geriatrics; geriatrik;

    Sammanfattning : Skeletal muscle accounts for the largest part of insulin-mediated glucose uptake. Insulin resistance (IR) is the main component of insulin resistance syndrome (IRS) and is an essential cause of a number of cardiovascular risk factors. LÄS MER

  5. 14. Early perturbations in lipid metabolism in insulin resistance

    Författare :Else Hellebö Johanson; Göteborgs universitet; []
    Nyckelord :insulin resistance; nateglinide; peak VO2; postprandial; relatives; triglyceride-rich lipoproteins; visceral fat; VLDL;

    Sammanfattning : Subjects with the Metabolic Syndrome with or without type 2 diabetes are at excess risk for developing cardiovascular disease. The mechanisms are still not completely understood. Resistance to insulin-stimulated glucose uptake is associated with several metabolic and hemostatic risk factors for cardiovascular disease. LÄS MER

  7. 15. Left ventricular hypertrophy and the insulin resistance syndrome

    Författare :Johan Sundström; Uppsala universitet; []
    Nyckelord :Medical sciences; Left ventricular hypertrophy; insulin; glucose; lipids; mortality; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Geriatrics; geriatrik;

    Sammanfattning : Left ventricular hypertrophy (LVH) and the insulin resistance syndrome are common conditions associated with a markedly increased cardiovascular risk. In a fairly large prospective longitudinal study of men from the general population, we found that an unfavorable serum fatty acid profile and components of the insulin resistance syndrome such as dyslipidemia, obesity and hypertension at age 50 predicted the prevalence of LVH at age 70. LÄS MER