Sökning: "insulin receptor substrate"
Visar resultat 21 - 25 av 38 avhandlingar innehållade orden insulin receptor substrate.
21. Molecular mechanisms of insulin action in human skeletal muscle and adipose tissue : implications for diabetes and obesity
Sammanfattning : Studies of animal models of type 2 diabetes mellitus implicate that impaired insulin signal transduction to glucose transport accounts for whole body insulin resistance in skeletal muscle and adipose tissue. The overall aim of the present thesis was to determine insulin signal transduction to glucose transport in human skeletal muscle and adipose tissue from type 2 diabetic patients and obese insulin resistant subjects. LÄS MER
22. The regulatory role of microRNA in human adipocytes and their link to insulin resistance
Sammanfattning : White adipose tissue (WAT) is a highly plastic organ which secretes a large number of peptide factors termed adipokines. Increased caloric intake increases WAT mass which results in marked alterations in the secretory pattern. This may be mediated via both transcriptional and post-transcriptional mechanisms. LÄS MER
23. Effect of hyperglycemia on glucose transport and intracellular signal transduction in skeletal muscle
Sammanfattning : Recent studies revealing the components of insulin signal transduction have raised the question of whether the defects in insulin signaling account for disturbed glucose metabolism in people with NIDDM. The major focus of this thesis is to elucidate the role of insulin signal transduction in the development of peripheral insulin resistance. LÄS MER
24. Applications of microdialysis in studies of the adrenergic regulation of lipolysis in human skeletal muscle and adipose tissue
Sammanfattning : Lipolysis, i.e., hydrolysis of triaeylglycerol to free fatty acids and glycerol, is a central process in lipid metabolism, and the regulation of lipid metabolism is altered in several common disorders, such as diabetes, obesity and atherosclerosis. LÄS MER
25. Molecular dissection of pathways regulating glucose and lipid metabolism using siRNA
Sammanfattning : Type 2 diabetes is a complex chronic disease that is associated with skeletal muscle insulin resistance. The aim of this thesis is to investigate pathways regulating glucose and lipid metabolism in human skeletal muscle. Whole body metabolism differs between men and women. LÄS MER